Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome
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DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 bindingMirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alphaDirect association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactionsPhosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinasesDYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cellsdDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in DrosophilaDYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down SyndromeMouse models of Down syndrome as a tool to unravel the causes of mental disabilitiesNutrient control of Drosophila longevityDyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeepingDYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1.DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survivalA chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibitionTargeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in miceTransgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration.Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21.Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1.Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk)The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiationThe transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase.Phosphorylation by Dyrk1A of clathrin coated vesicle-associated proteins: identification of the substrate proteins and the effects of phosphorylation.Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinaseMinibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammalsThe role of DYRK1A in neurodegenerative diseases.Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndromeRegulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1ATransient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling.Divergence of the genes on human chromosome 21 between human and other hominoids and variation of substitution rates among transcription unitsHuman neural stem cells: a new tool for studying cortical development in Down's syndrome.Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndromeDYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model.Gene dosage-dependent association of DYRK1A with the cytoskeleton in the brain and lymphocytes of down syndrome patients.Truncation of the Down syndrome candidate gene DYRK1A in two unrelated patients with microcephaly.Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome.Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome.Phosphorylation of Synaptojanin Differentially Regulates Endocytosis of Functionally Distinct Synaptic Vesicle Pools
P2860
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P2860
Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Human minibrain homologue (MNB ...... verexpression in Down syndrome
@ast
Human minibrain homologue (MNB ...... verexpression in Down syndrome
@en
Human minibrain homologue (MNB ...... verexpression in Down syndrome
@nl
type
label
Human minibrain homologue (MNB ...... verexpression in Down syndrome
@ast
Human minibrain homologue (MNB ...... verexpression in Down syndrome
@en
Human minibrain homologue (MNB ...... verexpression in Down syndrome
@nl
prefLabel
Human minibrain homologue (MNB ...... verexpression in Down syndrome
@ast
Human minibrain homologue (MNB ...... verexpression in Down syndrome
@en
Human minibrain homologue (MNB ...... verexpression in Down syndrome
@nl
P3181
P356
P1433
P1476
Human minibrain homologue (MNB ...... verexpression in Down syndrome
@en
P2093
Pritchard M
P304
P3181
P356
10.1006/GENO.1999.5775
P407
P577
1999-05-01T00:00:00Z