Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells - Wikidata - awgldk - TriplyDB

Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells

Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells

http://www.wikidata.org/entity/Q28146113

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Highlight: BRCA1 and BRCA2 proteins in breast cancer Scrib regulates PAK activity during the cell migration process The PI3K-PDK1 connection: more than just a road to PKB Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage Akt kinases in breast cancer and the results of adjuvant therapy Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play?Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40 Preclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomas.Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.Methylation of the tumor suppressor protein, BRCA1, influences its transcriptional cofactor function.Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells.Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci Targeting nonhomologous end-joining through epidermal growth factor receptor inhibition: rationale and strategies for radiosensitization.Akt: a double-edged sword in cell proliferation and genome stability.Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1.AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers.JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.An essential role for protein synthesis in oncogenic cellular transformation.Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1 AKT regulates BRCA1 stability in response to hormone signaling.The emerging role of the PI3-K-Akt pathway in prostate cancer progression.Targeting the epigenetics of the DNA damage response in breast cancer.AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma.Nuclear and mitochondrial signalling Akts in cardiomyocytes The efficacy of Herceptin therapies is influenced by the expression of other erbB receptors, their ligands and the activation of downstream signalling proteins Reversing Platinum Resistance in High-Grade Serous Ovarian Carcinoma: Targeting BRCA and the Homologous Recombination System BRCA1 16 years later: nuclear import and export processes.Opportunities and hurdles in the treatment of BRCA1-related breast cancer.An in vitro method for detecting chemical sensitization using human reconstructed skin models and its applicability to cosmetic, pharmaceutical, and medical device safety testing.Bone marrow-derived mesenchymal stem cells up-regulate acetylcholine receptor delta subunit through NRG/ErbB3-mediated mitogen-activated protein kinase pathway.Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.The valosin-containing protein (VCP) is a target of Akt signaling required for cell survival.Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells.Novel role for cyclin-dependent kinase 2 in neuregulin-induced acetylcholine receptor epsilon subunit expression in differentiated myotubes.Akt promotes tumorigenesis in part through modulating genomic instability via phosphorylating XLF.BRCA1 and BRCA2 bind Stat5a and suppress its transcriptional activity.Androgen receptor expression is regulated by the phosphoinositide 3-kinase/Akt pathway in normal and tumoral epithelial cells Characterization of dual PTEN and p53-targeting microRNAs identifies microRNA-638/Dnm2 as a two-hit oncogenic locus.

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Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells

http://www.wikidata.org/entity/Q28146113

description

1999 nî lūn-bûn

@nan

1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

1999年の論文

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1999年論文

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1999年論文

@zh-hant

1999年論文

@zh-hk

1999年論文

@zh-mo

1999年論文

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1999年论文

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name

Heregulin induces phosphorylat ...... ase/AKT in breast cancer cells

@ast

Heregulin induces phosphorylat ...... ase/AKT in breast cancer cells

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Heregulin induces phosphorylat ...... ase/AKT in breast cancer cells

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type

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Heregulin induces phosphorylat ...... ase/AKT in breast cancer cells

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Heregulin induces phosphorylat ...... ase/AKT in breast cancer cells

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Heregulin induces phosphorylat ...... ase/AKT in breast cancer cells

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prefLabel

Heregulin induces phosphorylat ...... ase/AKT in breast cancer cells

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Heregulin induces phosphorylat ...... ase/AKT in breast cancer cells

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Journal of Biological Chemistry

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Heregulin induces phosphorylat ...... ase/AKT in breast cancer cells

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P2093

A Papautsky

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H Avraham

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N Altiok

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P2860

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

Association of BRCA1 with Rad51 in mitotic and meiotic cells

Regulation of neuronal survival by the serine-threonine protein kinase Akt

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

Heregulin-stimulated acetylcholine receptor gene expression in muscle: requirement for MAP kinase and evidence for a parallel inhibitory pathway independent of electrical activity.

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase.

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2437187

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45

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274

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Julian Downward

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phosphorylation