about
On the origin of life in the zinc world: 1. Photosynthesizing, porous edifices built of hydrothermally precipitated zinc sulfide as cradles of life on EarthTesting electrostatic complementarity in enzyme catalysis: hydrogen bonding in the ketosteroid isomerase oxyanion holeAnatomy of enzyme channelsFundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymesBiological phosphoryl-transfer reactions: understanding mechanism and catalysisDesign and engineering of an O(2) transport proteinConformational Dynamics and Structural Plasticity Play Critical Roles in the Ubiquitin Recognition of a UIM DomainComparative Enzymology in the Alkaline Phosphatase Superfamily to Determine the Catalytic Role of an Active-Site Metal IonSnapshot of a Reaction Intermediate: Analysis of Benzoylformate Decarboxylase in Complex with a Benzoylphosphonate Inhibitor †Dissecting the paradoxical effects of hydrogen bond mutations in the ketosteroid isomerase oxyanion holeEvaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid IsomeraseQuantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active siteChasing acyl carrier protein through a catalytic cycle of lipid A productionThe role of protein dynamics in the evolution of new enzyme functionInterconversion of functional motions between mesophilic and thermophilic adenylate kinasesRelationship between Metabolic Fluxes and Sequence-Derived Properties of EnzymesDesigning artificial enzymes by intuition and computationUncovering the determinants of a highly perturbed tyrosine pKa in the active site of ketosteroid isomerase.Using shifts in amino acid frequency and substitution rate to identify latent structural characters in base-excision repair enzymesCombinatorial methods for small-molecule placement in computational enzyme design.Binding of PFOS to serum albumin and DNA: insight into the molecular toxicity of perfluorochemicals.Redesigning enzymes based on adaptive evolution for optimal function in synthetic metabolic pathwaysUsing unnatural amino acids to probe the energetics of oxyanion hole hydrogen bonds in the ketosteroid isomerase active site.Origins of catalysis by computationally designed retroaldolase enzymes.Update 1 of: Tunneling and dynamics in enzymatic hydride transfer.Single-molecule force spectroscopy approach to enzyme catalysis.Multiple levels of affinity-dependent DNA discrimination in Cre-LoxP recombination.Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.Catalytic reaction mechanism of acetylcholinesterase determined by Born-Oppenheimer ab initio QM/MM molecular dynamics simulations.Handicap-Recover Evolution Leads to a Chemically Versatile, Nucleophile-Permissive Protease.Tracing evolutionary footprints to identify novel gene functional linkagesDirect measurement of the protein response to an electrostatic perturbation that mimics the catalytic cycle in ketosteroid isomeraseExtensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site.Large-scale motions in the adenylate kinase solution ensemble: coarse-grained simulations and comparison with solution X-ray scattering.Conformational plasticity of an enzyme during catalysis: intricate coupling between cyclophilin A dynamics and substrate turnover.Gauging the flexibility of the active site in soybean lipoxygenase-1 (SLO-1) through an atom-centered density matrix propagation (ADMP) treatment that facilitates the sampling of rare events.Ground state destabilization from a positioned general base in the ketosteroid isomerase active site.Mechanistic implications of the cysteine-nicotinamide adduct in aldehyde dehydrogenase based on quantum mechanical/molecular mechanical simulationsForce-clamp spectroscopy detects residue co-evolution in enzyme catalysis.Free energies of chemical reactions in solution and in enzymes with ab initio quantum mechanics/molecular mechanics methods
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականին հրատարակուած գիտական յօդուած
@hyw
2003 թվականին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Challenges in enzyme mechanism and energetics
@ast
Challenges in enzyme mechanism and energetics
@en
Challenges in enzyme mechanism and energetics
@nl
type
label
Challenges in enzyme mechanism and energetics
@ast
Challenges in enzyme mechanism and energetics
@en
Challenges in enzyme mechanism and energetics
@nl
prefLabel
Challenges in enzyme mechanism and energetics
@ast
Challenges in enzyme mechanism and energetics
@en
Challenges in enzyme mechanism and energetics
@nl
P3181
P1476
Challenges in enzyme mechanism and energetics
@en
P2093
Daniel Herschlag
P304
P3181
P356
10.1146/ANNUREV.BIOCHEM.72.121801.161617
P407
P577
2003-04-10T00:00:00Z