Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation
about
The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase CContributions of human enzymes in carcinogen metabolismUDP-glucuronosyltransferase 1A10: activity against the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and a potential role for a novel UGT1A10 promoter deletion polymorphism in cancer susceptibility.Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificityRegulated phosphorylation of a major UDP-glucuronosyltransferase isozyme by tyrosine kinases dictates endogenous substrate selection for detoxification.Therapeutic promises of 2-methoxyestradiol and its drug disposition challengesPharmGKB summary: ibuprofen pathways.Phenylalanine(90) and phenylalanine(93) are crucial amino acids within the estrogen binding site of the human UDP-glucuronosyltransferase 1A10.Protein kinase Cα and Src kinase support human prostate-distributed dihydrotestosterone-metabolizing UDP-glucuronosyltransferase 2B15 activity.First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics.Novel identification of UDP-glucuronosyltransferase 1A10 as an estrogen-regulated target gene.Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteersIdentification of UDP-glucuronosyltransferase 1A10 in non-malignant and malignant human breast tissues.Assessing the regioselectivity of OleD-catalyzed glycosylation with a diverse set of acceptors.Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancerTranscriptional regulation of human UDP-glucuronosyltransferase genes.Biotransformation of xenobiotics in the human colon and rectum and its association with colorectal cancer.Regulation of uridine diphosphate-glucuronosyltransferase 1A3 activity by protein phosphorylation.Role for protein kinase C delta in the functional activity of human UGT1A6: implications for drug-drug interactions between PKC inhibitors and UGT1A6.Glucuronidation of bioflavonoids by human UGT1A10: structure-function relationships.Pathway-based approaches for assessment of real-time exposure to an estrogenic wastewater treatment plant effluent on fathead minnow reproduction.Effect of common exon variant (p.P364L) on drug glucuronidation by the human UDP-glucuronosyltransferase 1 family.
P2860
Q24321904-5287ED03-1A4B-49EA-8AB9-CFF79143DBEDQ30520640-FC827DB7-FB97-4FB1-850A-3B69865C9B52Q33714575-848C4D6E-25D6-4D97-AA3C-67592FC46F48Q33771993-0F5DF499-CEE1-41E6-B4F1-E95C4C5A06B7Q34489142-F21F0AE2-A6C8-4E82-BB0D-6A396F17AFFBQ34691671-BEF8BF46-27A3-42DA-B79C-980AB6F3420EQ35164718-CCF6DD10-85FD-4CDF-A68E-EA1CE0AC7A5BQ35691729-F29820E2-AE9D-4981-8419-6DD6C283FF00Q36097980-A7E93722-F9CE-49F8-94D9-28004589BD36Q36132293-416C663B-BC91-4540-AB52-01AA281D8E12Q36453603-BE02006D-E909-4207-8E89-22DA7B30301FQ36629228-63C76E74-1B8C-46F2-80B2-DB3D24BB0894Q36691192-E9CDEF76-61C4-434E-A6E7-3C2AE74E65DDQ36715634-E4CA6787-2B3E-4B19-B444-78F1E13E7057Q37262571-8033165C-D4F3-4C57-AEAC-5B8405784483Q38261875-D8F34A04-8A0B-4092-B764-357C860CA6ECQ38357424-B0365153-B68A-4E90-8B30-72446EC9A12DQ38861758-17ED4F0F-DAA5-4EFC-9CC4-F183B015A6A9Q39733356-0EAC95DC-6501-405D-A7CF-E297E37DE390Q40397635-D1C4259F-8356-4153-A448-E42754EED8D5Q43338049-E9610F4B-EEFA-4FC3-952E-4F7AAEECA6A5Q51766831-121A2F93-C4EB-4D19-9302-CA5F0ACED119
P2860
Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Gastrointestinally distributed ...... , depends upon phosphorylation
@ast
Gastrointestinally distributed ...... , depends upon phosphorylation
@en
Gastrointestinally distributed ...... , depends upon phosphorylation
@nl
type
label
Gastrointestinally distributed ...... , depends upon phosphorylation
@ast
Gastrointestinally distributed ...... , depends upon phosphorylation
@en
Gastrointestinally distributed ...... , depends upon phosphorylation
@nl
prefLabel
Gastrointestinally distributed ...... , depends upon phosphorylation
@ast
Gastrointestinally distributed ...... , depends upon phosphorylation
@en
Gastrointestinally distributed ...... , depends upon phosphorylation
@nl
P2093
P2860
P356
P1476
Gastrointestinally distributed ...... , depends upon phosphorylation
@en
P2093
Bhabadeb Chowdhury
Ida S Owens
Marco Ciotti
Masao Hartori
Meselhy R Meselhy
Nikhil K Basu
Shigeki Kubota
P2860
P304
P356
10.1074/JBC.M401396200
P407
P577
2004-07-02T00:00:00Z