Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants
about
The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitorsKinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving groupContribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesteraseResistance-associated point mutations in insecticide-insensitive acetylcholinesteraseOxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging.Catalytic reaction mechanism of acetylcholinesterase determined by Born-Oppenheimer ab initio QM/MM molecular dynamics simulations.Acetylcholinesterase: diffusional encounter rate constants for dumbbell models of ligandAcetylcholinesterase inhibitors: pharmacology and toxicology.Surface display and bioactivity of Bombyx mori acetylcholinesterase on Pichia pastoris.Characterization of 12 silent alleles of the human butyrylcholinesterase (BCHE) geneThe genome of Strongyloides spp. gives insights into protein families with a putative role in nematode parasitism.Conformation gating as a mechanism for enzyme specificity.Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases.Negatively charged amino acid residues in the nicotinic receptor delta subunit that contribute to the binding of acetylcholine.Studying the roles of W86, E202, and Y337 in binding of acetylcholine to acetylcholinesterase using a combined molecular dynamics and multiple docking approachStructure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6.Epitope mapping of form-specific and nonspecific antibodies to acetylcholinesterase.Analysis of synaptic transmission in the neuromuscular junction using a continuum finite element model.Cloning, sequencing and functional expression of an acetylcholinesterase gene from the yellow fever mosquito Aedes aegypti.Interaction kinetics of reversible inhibitors and substrates with acetylcholinesterase and its fasciculin 2 complex.Allosteric control of acetylcholinesterase catalysis by fasciculin.Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes.Structural insights into substrate traffic and inhibition in acetylcholinesteraseTheoretical analysis of the structure of the peptide fasciculin and its docking to acetylcholinesterase.Influence of the water structure on the acetylcholinesterase efficiencyMultiple binding sites involved in the effect of choline esters on decarbamoylation of monomethylcarbamoyl- or dimethylcarbamoly-acetylcholinesterase.Identification of a third Boophilus microplus (Acari: Ixodidae) cDNA presumptively encoding an acetylcholinesterase.Solubilization, molecular forms, purification and substrate specificity of two acetylcholinesterases in the medicinal leech (Hirudo medicinalis).Expression and processing of vertebrate acetylcholinesterase in the yeast Pichia pastoris.Expression of recombinant human acetylcholinesterase in transgenic tomato plants.Inhibitors of different structure induce distinguishing conformations in the omega loop, Cys69-Cys96, of mouse acetylcholinesterase.Structural bioinformatics and QSAR analysis applied to the acetylcholinesterase and bispyridinium aldoximes.Unbinding of fluorinated oxime drug from the AChE gorge in polarizable water: a well-tempered metadynamics study.On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach.Structural modifications of the omega loop in human acetylcholinesterase.Engineering resistance to 'aging' of phosphylated human acetylcholinesterase. Role of hydrogen bond network in the active center.
P2860
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P2860
Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants
description
1992 nî lūn-bûn
@nan
1992 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Expression of recombinant acet ...... rties of glutamate 199 mutants
@ast
Expression of recombinant acet ...... rties of glutamate 199 mutants
@en
Expression of recombinant acet ...... rties of glutamate 199 mutants
@nl
type
label
Expression of recombinant acet ...... rties of glutamate 199 mutants
@ast
Expression of recombinant acet ...... rties of glutamate 199 mutants
@en
Expression of recombinant acet ...... rties of glutamate 199 mutants
@nl
prefLabel
Expression of recombinant acet ...... rties of glutamate 199 mutants
@ast
Expression of recombinant acet ...... rties of glutamate 199 mutants
@en
Expression of recombinant acet ...... rties of glutamate 199 mutants
@nl
P2093
P356
P1433
P1476
Expression of recombinant acet ...... rties of glutamate 199 mutants
@en
P2093
C Bongiorno
K MacPhee-Quigley
S Kawamoto
P304
P356
10.1021/BI00155A032
P407
P577
1992-10-13T00:00:00Z