Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation
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Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursorsHypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotypePBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter regionCytosolic sequestration of Prep1 influences early stages of T cell development.Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β-SMAD3 pathway in non-small cell lung adenocarcinoma.Homeodomain transcription factor and tumor suppressor Prep1 is required to maintain genomic stability.ChIP-Seq and RNA-Seq analyses identify components of the Wnt and Fgf signaling pathways as Prep1 target genes in mouse embryonic stem cells.Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma.HOXB1 Is a Tumor Suppressor Gene Regulated by miR-3175 in Glioma.Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac deathPrep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis.Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates.The abrogation of the HOXB7/PBX2 complex induces apoptosis in melanoma through the miR-221&222-c-FOS pathway.MEIS1, PREP1, and PBX4 are differentially expressed in acute lymphoblastic leukemia: association of MEIS1 expression with higher proliferation and chemotherapy resistance.The flexibility of a homeodomain transcription factor heterodimer and its allosteric regulation by DNA binding.Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress.p160 Myb-binding protein interacts with Prep1 and inhibits its transcriptional activity.Prep1 directly regulates the intrinsic apoptotic pathway by controlling Bcl-XL levels.
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P2860
Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation
description
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2003
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im Oktober 2003 veröffentlichter wissenschaftlicher Artikel
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scientific article (publication date: 3 October 2003)
@en
vedecký článok (publikovaný 2003/10/03)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/10/03)
@nl
наукова стаття, опублікована в жовтні 2003
@uk
name
Overexpression of PREP-1 in F9 ...... by preventing its degradation
@ast
Overexpression of PREP-1 in F9 ...... by preventing its degradation
@en
Overexpression of PREP-1 in F9 ...... by preventing its degradation
@nl
type
label
Overexpression of PREP-1 in F9 ...... by preventing its degradation
@ast
Overexpression of PREP-1 in F9 ...... by preventing its degradation
@en
Overexpression of PREP-1 in F9 ...... by preventing its degradation
@nl
prefLabel
Overexpression of PREP-1 in F9 ...... by preventing its degradation
@ast
Overexpression of PREP-1 in F9 ...... by preventing its degradation
@en
Overexpression of PREP-1 in F9 ...... by preventing its degradation
@nl
P2860
P356
P1476
Overexpression of PREP-1 in F9 ...... by preventing its degradation
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P2093
Elena Longobardi
Francesco Blasi
P2860
P304
P356
10.1074/JBC.M304704200
P407
P577
2003-10-03T00:00:00Z