Activation and mitochondrial translocation of protein kinase Cdelta are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells
about
Down-regulation of pyruvate dehydrogenase phosphatase in obese subjects is a defect that signals insulin resistanceTyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signalingStarvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidneyDysregulated pyruvate dehydrogenase complex in Zucker diabetic fatty rats.Low muscle glycogen and elevated plasma free fatty acid modify but do not prevent exercise-induced PDH activation in human skeletal muscle.Regulation of pyruvate metabolism and human diseaseEssential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1.Isozyme-specific interaction of protein kinase Cδ with mitochondria dissected using live cell fluorescence imaging.Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart.In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonanceLack of mitochondria-generated acetyl-CoA by pyruvate dehydrogenase complex downregulates gene expression in the hepatic de novo lipogenic pathway.Age-related impairments in skeletal muscle PDH phosphorylation and plasma lactate are indicative of metabolic inflexibility and the effects of exercise training.JAK-STAT signaling and myocardial glucose metabolism.Lipid signaling on the mitochondrial surface.Regulation of muscle pyruvate dehydrogenase complex in insulin resistance: effects of exercise and dichloroacetateRegulation of pyruvate metabolism in metabolic-related diseases.Protein kinase Cδ but not PKCα is involved in insulin-induced glucose metabolism in hepatocytes.Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Cdelta.Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate.Metabolic flexibility is conserved in diabetic myotubes.Protein kinase Calpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase.Protein kinase C-alpha regulates insulin action and degradation by interacting with insulin receptor substrate-1 and 14-3-3 epsilon.Insulin stimulation of pyruvate dehydrogenase in adipocytes involves two distinct signalling pathways.Carbohydrate ingestion reduces skeletal muscle acetylcarnitine availability but has no effect on substrate phosphorylation at the onset of exercise in man.The diacylglycerol and protein kinase C pathways are not involved in insulin signalling in primary rat hepatocytes.Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria.Skeletal muscle type comparison of pyruvate dehydrogenase phosphatase activity and isoform expression: effects of obesity and endurance training.Skeletal muscle fiber type comparison of pyruvate dehydrogenase phosphatase activity and isoform expression in fed and food-deprived rats.Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.The relationship between human skeletal muscle pyruvate dehydrogenase phosphatase activity and muscle aerobic capacity.
P2860
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P2860
Activation and mitochondrial translocation of protein kinase Cdelta are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Activation and mitochondrial t ...... vity in muscle and liver cells
@ast
Activation and mitochondrial t ...... vity in muscle and liver cells
@en
Activation and mitochondrial t ...... vity in muscle and liver cells
@nl
type
label
Activation and mitochondrial t ...... vity in muscle and liver cells
@ast
Activation and mitochondrial t ...... vity in muscle and liver cells
@en
Activation and mitochondrial t ...... vity in muscle and liver cells
@nl
prefLabel
Activation and mitochondrial t ...... vity in muscle and liver cells
@ast
Activation and mitochondrial t ...... vity in muscle and liver cells
@en
Activation and mitochondrial t ...... vity in muscle and liver cells
@nl
P2093
P2860
P356
P1476
Activation and mitochondrial t ...... vity in muscle and liver cells
@en
P2093
F Beguinot
G Vigliotta
M A Maitan
P Formisano
P2860
P304
P356
10.1074/JBC.M105451200
P407
P577
2001-11-30T00:00:00Z