P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries - Wikidata - awgldk - TriplyDB

P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries

P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries

http://www.wikidata.org/entity/Q28196936

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Central role of the P2Y12 receptor in platelet activation International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts Purinergic P2Y12 Receptor Activation in Eosinophils and the Schistosomal Host Response Clopidogrel for the secondary prevention of stroke Primary and secondary agonists can use P2X(1) receptors as a major pathway to increase intracellular Ca(2+) in the human platelet Platelet P2Y12 is involved in murine pulmonary metastasis Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques Variable effect of P2Y12 inhibition on platelet thrombus volume in flowing blood.RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy.Increased platelet activation and thrombosis in transgenic mice expressing constitutively active P2Y12.Development of a perfusion chamber assay to study in real time the kinetics of thrombosis and the antithrombotic characteristics of antiplatelet drugs Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model.New insights into the haemostatic function of platelets.Endobrevin/VAMP-8-dependent dense granule release mediates thrombus formation in vivo Role for ADAP in shear flow-induced platelet mechanotransduction.Purinergic P2Y₁₄ receptor modulates stress-induced hematopoietic stem/progenitor cell senescence Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents.Shaping the platelet response to vascular injury.Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling.The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism.In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation.Humanizing thrombi in mice.Characterization of a novel function-blocking antibody targeted against the platelet P2Y1 receptor.Critical role for Syk in responses to vascular injury.Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2 Platelet Gi protein Gαi2 is an essential mediator of thrombo-inflammatory organ damage in mice.Rap1-Rac1 circuits potentiate platelet activation Extract from Aronia melanocarpa fruits potentiates the inhibition of platelet aggregation in the presence of endothelial cells Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.Purines as potential morphogens during embryonic development.Ectonucleotide triphosphate diphosphohydrolase-1 (CD39) mediates resistance to occlusive arterial thrombus formation after vascular injury in mice.Gallic Acid Attenuates Platelet Activation and Platelet-Leukocyte Aggregation: Involving Pathways of Akt and GSK3β Clopidogrel-Induced Recurrent Polyarthritis.The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.

P2860

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P2860

P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries

http://www.wikidata.org/entity/Q28196936

description

2003 nî lūn-bûn

@nan

2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

P2Y12 regulates platelet adhes ...... stability in injured arteries

@ast

P2Y12 regulates platelet adhes ...... stability in injured arteries

@en

P2Y12 regulates platelet adhes ...... stability in injured arteries

@nl

type

label

P2Y12 regulates platelet adhes ...... stability in injured arteries

@ast

P2Y12 regulates platelet adhes ...... stability in injured arteries

@en

P2Y12 regulates platelet adhes ...... stability in injured arteries

@nl

prefLabel

P2Y12 regulates platelet adhes ...... stability in injured arteries

@ast

P2Y12 regulates platelet adhes ...... stability in injured arteries

@en

P2Y12 regulates platelet adhes ...... stability in injured arteries

@nl

P1433

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P2860

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P1433

Journal of Clinical Investigation

P1476

P2Y12 regulates platelet adhes ...... stability in injured arteries

@en

P2093

Beverley Koller

http://www.w3.org/2001/XMLSchema#string

David R Phillips

http://www.w3.org/2001/XMLSchema#string

Diana Vincent

http://www.w3.org/2001/XMLSchema#string

Francis DeGuzman

http://www.w3.org/2001/XMLSchema#string

Marzena Jurek

http://www.w3.org/2001/XMLSchema#string

Pamela B Conley

http://www.w3.org/2001/XMLSchema#string

Patrick Andre

http://www.w3.org/2001/XMLSchema#string

Suzanne M Delaney

http://www.w3.org/2001/XMLSchema#string

Thomas LaRocca

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P2860

Identification of the platelet ADP receptor targeted by antithrombotic drugs

Cloning of the murine platelet glycoprotein Ibalpha gene highlighting species-specific platelet adhesion

Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study

Platelet CD40 ligand (CD40L)--subcellular localization, regulation of expression, and inhibition by clopidogrel

Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation

Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain

Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial

A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease

Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP

Impaired activation of murine platelets lacking G alpha(i2)

P304

398-406

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scholarly article

P356

10.1172/JCI17864

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P433

3

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P478

112

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P577

2003-08-01T00:00:00Z

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P698

12897207

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P932

166294

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