Biosynthetic Studies of Daunorubicin and Tetracenomycin C
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Purification, properties, and characterization of recombinant Streptomyces sp. strain C5 DoxA, a cytochrome P-450 catalyzing multiple steps in doxorubicin biosynthesisDoxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.The Streptomyces peucetius dpsC gene determines the choice of starter unit in biosynthesis of the daunorubicin polyketide.The structure of ActVA-Orf6, a novel type of monooxygenase involved in actinorhodin biosynthesis.Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanismInsight into the Molecular Basis of Aromatic Polyketide Cyclization: Crystal Structure and in Vitro Characterization of WhiE-ORFVIExpanding our understanding of sequence-function relationships of type II polyketide biosynthetic gene clusters: bioinformatics-guided identification of Frankiamicin A from Frankia sp. EAN1pecCloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clustersMicrobial polyketide synthases: more and more prolific.Cyclization of aromatic polyketides from bacteria and fungiCloning and heterologous expression of three type II PKS gene clusters from Streptomyces bottropensis.Oxytetracycline biosynthesis.Engineered biosynthesis of aklanonic acid analoguesEngineered polyketide biosynthesis and biocatalysis in Escherichia coli.Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase.Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycinBiosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unitPolyketide and non-ribosomal peptide synthases: falling together by coming apart.The EntF and EntE adenylation domains of Escherichia coli enterobactin synthetase: sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates.Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthaseA putative polyketide-synthesis protein XC5357 from Xanthomonas campestris: heterologous expression, crystallization and preliminary X-ray analysis.Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis.Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.Nitrososynthase-triggered oxidative carbon-carbon bond cleavage in baumycin biosynthesis.Antitumor compounds from marine actinomycetes.Biotechnology of polyketides: new breath of life for the novel antibiotic genetic pathways discovery through metagenomicsHutchinson's legacy: keeping on polyketide biosynthesis.Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis.Engineering anthracycline biosynthesis toward angucyclines.Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism.The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins.Genetic interrelations in the actinomycin biosynthetic gene clusters of Streptomyces antibioticus IMRU 3720 and Streptomyces chrysomallus ATCC11523, producers of actinomycin X and actinomycin C.A novel quinone-forming monooxygenase family involved in modification of aromatic polyketides.Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway.First Total Syntheses of Tetracenomycins C and X.Special issue of The Journal of Antibiotics dedicated to the late Professor C Richard Hutchinson.Identification of Late-Stage Glycosylation Steps in the Biosynthetic Pathway of the Anthracycline Nogalamycin
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P2860
Biosynthetic Studies of Daunorubicin and Tetracenomycin C
description
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1997
@ast
im November 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 10 November 1997)
@en
vedecký článok (publikovaný 1997/11/10)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/11/10)
@nl
наукова стаття, опублікована в листопаді 1997
@uk
مقالة علمية (نشرت في 10-11-1997)
@ar
name
Biosynthetic Studies of Daunorubicin and Tetracenomycin C
@ast
Biosynthetic Studies of Daunorubicin and Tetracenomycin C
@en
Biosynthetic Studies of Daunorubicin and Tetracenomycin C
@nl
type
label
Biosynthetic Studies of Daunorubicin and Tetracenomycin C
@ast
Biosynthetic Studies of Daunorubicin and Tetracenomycin C
@en
Biosynthetic Studies of Daunorubicin and Tetracenomycin C
@nl
prefLabel
Biosynthetic Studies of Daunorubicin and Tetracenomycin C
@ast
Biosynthetic Studies of Daunorubicin and Tetracenomycin C
@en
Biosynthetic Studies of Daunorubicin and Tetracenomycin C
@nl
P356
P1433
P1476
Biosynthetic Studies of Daunorubicin and Tetracenomycin C
@en
P2093
C. Richard Hutchinson
P304
P356
10.1021/CR960022X
P407
P577
1997-11-10T00:00:00Z