Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF - Wikidata - awgldk - TriplyDB

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

http://www.wikidata.org/entity/Q28202817

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Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain Recognition of the Activated States of Gα13 by the rgRGS Domain of PDZRhoGEF Identification of Critical Residues in G 13 for Stimulation of p115RhoGEF Activity and the Structure of the G 13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.CCK activates RhoA and Rac1 differentially through Galpha13 and Galphaq in mouse pancreatic acini.The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis.Cholecystokinin-mediated RhoGDI phosphorylation via PKCα promotes both RhoA and Rac1 signaling.Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13 Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain Lsc activity is controlled by oligomerization and regulates integrin adhesion.Regulation and physiological functions of G12/13-mediated signaling pathways.Adenylyl cyclases in the digestive system.Coordinate Galpha13 and Wnt6-beta-catenin signaling in F9 embryonal carcinoma cells is required for primitive endoderm differentiation.A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion.Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF Chimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13.Differences in Galpha12- and Galpha13-mediated plasma membrane recruitment of p115-RhoGEF.Differential contribution of GTPase activation and effector antagonism to the inhibitory effect of RGS proteins on Gq-mediated signaling in vivo.Adenylyl cyclase 6 mediates the action of cyclic AMP-dependent secretagogues in mouse pancreatic exocrine cells via protein kinase A pathway activation.Arhgef1 negatively regulates neurite outgrowth through activation of RhoA signaling pathways.

P2860

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P2860

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

http://www.wikidata.org/entity/Q28202817

description

2003 nî lūn-bûn

@nan

2003 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի մարտին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

@ast

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

@en

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

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type

label

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

@ast

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

@en

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

@nl

prefLabel

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

@ast

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

@en

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

@nl

P1433

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P1476

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P2860

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P407

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P698

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P356

P1433

Journal of Biological Chemistry

P1476

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

@en

P2093

Clark D Wells

http://www.w3.org/2001/XMLSchema#string

Paul C Sternweis

http://www.w3.org/2001/XMLSchema#string

Stephen R Sprang

http://www.w3.org/2001/XMLSchema#string

William D Singer

http://www.w3.org/2001/XMLSchema#string

Zhe Chen

http://www.w3.org/2001/XMLSchema#string

P2860

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

Structure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complex

Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling

Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A

Structure of the rgRGS domain of p115RhoGEF

GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

P304

9912-9

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scholarly article

P356

10.1074/JBC.M212695200

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P407

P433

11

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P478

278

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P577

2003-03-14T00:00:00Z

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P698

12525488

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