NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway - Wikidata - awgldk - TriplyDB

NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway

NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway

http://www.wikidata.org/entity/Q28203601

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Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D Resistance to cytarabine induces the up-regulation of NKG2D ligands and enhances natural killer cell lysis of leukemic cells Comparative genomics of natural killer cell receptor gene clusters.Impact of the MICA-129Met/Val Dimorphism on NKG2D-Mediated Biological Functions and Disease Risks Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases Protein Kinase Inhibitors CK59 and CID755673 Alter Primary Human NK Cell Effector Functions Up on the tightrope: natural killer cell activation and inhibition An approach to the immunophenotypic features of circulating CD4⁺NKG2D⁺ T cells in invasive cervical carcinoma.Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling Human IgG1 antibodies antagonizing activating receptor NKG2D on natural killer cells Role of major histocompatibility complex variation in graft-versus-host disease after hematopoietic cell transplantation.Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells.Ligand dimensions are important in controlling NK-cell responses.A truncated human NKG2D splice isoform negatively regulates NKG2D-mediated function.Opportunities and limitations of natural killer cells as adoptive therapy for malignant disease Costimulation of dendritic epidermal gammadelta T cells by a new NKG2D ligand expressed specifically in the skin NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.Super-resolution imaging of remodeled synaptic actin reveals different synergies between NK cell receptors and integrins.DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production.The C-type lectin OCILRP2 costimulates EL4 T cell activation via the DAP12-Raf-MAP kinase pathway.NK cells: immune cross-talk and therapeutic implications.Natural killer cell receptors for major histocompatibility complex class I and related molecules in cytomegalovirus infection.Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicity.Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the γc cytokines and TGF-β1.Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation Antitumor activity of a rhenium (I)-diselenoether complex in experimental models of human breast cancer Activation of natural killer cells: underlying molecular mechanisms revealed.Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells.Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion Multiplicity and plasticity of natural killer cell signaling pathways.Interplay of natural killer cells and their receptors with the adaptive immune response.The role of SH3BP2 in the pathophysiology of cherubism.Cysteinyl leukotrienes mediate lymphokine killer activity induced by NKG2D and IL-15 in cytotoxic T cells during celiac disease.Increased Natural Killer Cell Activation in HIV-Infected Immunologic Non-Responders Correlates with CD4+ T Cell Recovery after Antiretroviral Therapy and Viral Suppression.The MICA-129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation.DNA damage and tumor surveillance: one trigger for two pathways.Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells.

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NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway

http://www.wikidata.org/entity/Q28203601

description

2003 nî lūn-bûn

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2003 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հունիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

NKG2D-DAP10 triggers human NK ...... independent regulatory pathway

@ast

NKG2D-DAP10 triggers human NK ...... independent regulatory pathway

@en

NKG2D-DAP10 triggers human NK ...... independent regulatory pathway

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type

label

NKG2D-DAP10 triggers human NK ...... independent regulatory pathway

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NKG2D-DAP10 triggers human NK ...... independent regulatory pathway

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NKG2D-DAP10 triggers human NK ...... independent regulatory pathway

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prefLabel

NKG2D-DAP10 triggers human NK ...... independent regulatory pathway

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NKG2D-DAP10 triggers human NK ...... independent regulatory pathway

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NKG2D-DAP10 triggers human NK ...... independent regulatory pathway

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Nature Immunology

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NKG2D-DAP10 triggers human NK ...... independent regulatory pathway

@en

P2093

Christopher J Dick

http://www.w3.org/2001/XMLSchema#string

Daniel D Billadeau

http://www.w3.org/2001/XMLSchema#string

Jadee L Upshaw

http://www.w3.org/2001/XMLSchema#string

Paul J Leibson

http://www.w3.org/2001/XMLSchema#string

Renee A Schoon

http://www.w3.org/2001/XMLSchema#string

P2860

Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA

An activating immunoreceptor complex formed by NKG2D and DAP10

ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor

Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells

Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions

NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation

Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D

Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity

SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors

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557-64

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scholarly article

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1381872

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10.1038/NI929

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P433

6

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4

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2003-06-01T00:00:00Z

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10764877

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1005523628

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12740575

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