Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides
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Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- miceMatriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndromeLEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interactionSpink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivityHuman tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patientsKallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade.Skin barrier functionEvolutionary history of tissue kallikreinsMembrane-anchored serine proteases in vertebrate cell and developmental biologyGenetics and genomics of asthma and allergic diseases.Gene expression profiling in pachyonychia congenita skinThe immunogenetics of asthma and eczema: a new focus on the epithelium.Co-regulation of p16INK4A and migratory genes in culture conditions that lead to premature senescence in human keratinocytes.Stratum corneum defensive functions: an integrated view.KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.The kallikrein world: an update on the human tissue kallikreins.Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanismsTrends in stratum corneum research and the management of dry skin conditions.A potential role for tissue kallikrein-related peptidases in human cervico-vaginal physiology.New insights into the functional mechanisms and clinical applications of the kallikrein-related peptidase family.Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis.Congenital hair loss disorders: rare, but not too rare.Unleashing the therapeutic potential of human kallikrein-related serine proteases.Kallikrein-related peptidases (KLKs) as emerging therapeutic targets: focus on prostate cancer and skin pathologies.Netherton Syndrome: A Genotype-Phenotype Review.Netherton syndrome in one Chinese adult with a novel mutation in the SPINK5 gene and immunohistochemical studies of LEKTIRegulation of serine protease inhibitor Kazal type-5 (SPINK5) gene expression in the keratinocytes.Epithelial genes in chronic rhinosinusitis with and without nasal polypsTopical treatment of Netherton's syndrome with tacrolimus ointment without significant systemic absorption.Lethal, neonatal ichthyosis with increased proteolytic processing of filaggrin in a mouse model of Netherton syndrome.LEKTI demonstrable by immunohistochemistry of the skin: a potential diagnostic skin test for Netherton syndrome.An infant with Netherton syndrome and persistent pulmonary hypertension requiring extracorporeal membrane oxygenation.Netherton syndrome with extensive skin peeling and failure to thrive due to a homozygous frameshift mutation in SPINK5.Netherton syndrome in two Japanese siblings with a novel mutation in the SPINK5 gene: immunohistochemical studies of LEKTI and other epidermal molecules.Topical pimecrolimus: a novel therapeutic option for Netherton syndrome.Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI).hK5 and hK7, two serine proteinases abundant in human skin, are inhibited by LEKTI domain 6.SPINK5: a gene for atopic dermatitis and asthma.Treatment of ichthyosis and hypernatremia in a patient with Netherton syndrome with a SPINK5 c.153delT mutation using kallikrein inhibiting ointment.Aberrant human tissue kallikrein levels in the stratum corneum and serum of patients with psoriasis: dependence on phenotype, severity and therapy
P2860
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P2860
Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Elevated stratum corneum hydro ...... ion by SPINK5-derived peptides
@ast
Elevated stratum corneum hydro ...... ion by SPINK5-derived peptides
@en
Elevated stratum corneum hydro ...... ion by SPINK5-derived peptides
@nl
type
label
Elevated stratum corneum hydro ...... ion by SPINK5-derived peptides
@ast
Elevated stratum corneum hydro ...... ion by SPINK5-derived peptides
@en
Elevated stratum corneum hydro ...... ion by SPINK5-derived peptides
@nl
prefLabel
Elevated stratum corneum hydro ...... ion by SPINK5-derived peptides
@ast
Elevated stratum corneum hydro ...... ion by SPINK5-derived peptides
@en
Elevated stratum corneum hydro ...... ion by SPINK5-derived peptides
@nl
P2093
P1476
Elevated stratum corneum hydro ...... ion by SPINK5-derived peptides
@en
P2093
Kazuhiko Takehara
Kiyofumi Saijoh
Minoru Takata
Nahoko Komatsu
Norio Otsuki
Osamu Amano
P304
P356
10.1046/J.0022-202X.2001.01663.X
P407
P577
2002-03-01T00:00:00Z
P5875
P6179
1041083940