Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint
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Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases.Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphataseCdc7-Dbf4 and the human S checkpoint response to UVCPhosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolaritySCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphataseChk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 bindingPro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domainCasein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction.Telekin suppresses human hepatocellular carcinoma cells in vitro by inducing G2/M phase arrest via the p38 MAPK signaling pathway.Cdc25A-driven proliferation regulates CD62L levels and lymphocyte movement in response to interleukin-7.Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuitA phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1.Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis.Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication.Checking on DNA damage in S phase.Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratioSynthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cellsZebrafish cdc25a is expressed during early development and limiting for post-blastoderm cell cycle progression.Cytokine-driven cell cycling is mediated through Cdc25A.GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.CDC25 phosphatases in cancer cells: key players? Good targets?Interlinking interleukin-7.Acetylation and deacetylation of Cdc25A constitutes a novel mechanism for modulating Cdc25A functions with implications for cancer.In vivo roles of CDC25 phosphatases: biological insight into the anti-cancer therapeutic targetsNon-classical p38 map kinase functions: cell cycle checkpoints and survival.DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress.CRL Ubiquitin Ligases and DNA Damage Response.Latex of Euphorbia antiquorum-induced S-phase arrest via active ATM kinase and MAPK pathways in human cervical cancer HeLa cells.3,3'-Diindolylmethane inhibits breast cancer cell growth via miR-21-mediated Cdc25A degradation.Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle.Phosphorylation of CDC25A on SER283 in late S/G2 by CDK/cyclin complexes accelerates mitotic entry.Cdc25A serine 123 phosphorylation couples centrosome duplication with DNA replication and regulates tumorigenesis.microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.Nitrosative stress suppresses checkpoint activation after DNA synthesis inhibition.Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway.Ciclopirox activates ATR-Chk1 signaling pathway leading to Cdc25A protein degradation.
P2860
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P2860
Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint
description
2003 nî lūn-bûn
@nan
2003 թուականին հրատարակուած գիտական յօդուած
@hyw
2003 թվականին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Regulation of human Cdc25A sta ...... activate a S phase checkpoint
@ast
Regulation of human Cdc25A sta ...... activate a S phase checkpoint
@en
Regulation of human Cdc25A sta ...... activate a S phase checkpoint
@nl
type
label
Regulation of human Cdc25A sta ...... activate a S phase checkpoint
@ast
Regulation of human Cdc25A sta ...... activate a S phase checkpoint
@en
Regulation of human Cdc25A sta ...... activate a S phase checkpoint
@nl
prefLabel
Regulation of human Cdc25A sta ...... activate a S phase checkpoint
@ast
Regulation of human Cdc25A sta ...... activate a S phase checkpoint
@en
Regulation of human Cdc25A sta ...... activate a S phase checkpoint
@nl
P2093
P356
P1433
P1476
Regulation of human Cdc25A sta ...... activate a S phase checkpoint
@en
P2093
Albert J Fornace
Anastasia Goloudina
Daria B Chervyakova
Dmitry V Bulavin
Hiroshi Yamaguchi
P356
10.4161/CC.2.5.482
P407
P577
2003-01-01T00:00:00Z