A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity
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Childhood obesityGenome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors.Novel genes involved in severe early-onset obesity revealed by rare copy number and sequence variantsChaperoning G protein-coupled receptors: from cell biology to therapeuticsResearch resource: Gene profiling of G protein-coupled receptors in the arcuate nucleus of the female.Prolylcarboxypeptidase (PRCP) as a new target for obesity treatmentPolymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility.Physiological roles of the melanocortin MC₃ receptor.Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptorThe human obesity gene map: the 2002 update.Biased signaling in naturally occurring mutations in human melanocortin-3 receptor gene.Gamma-MSH, sodium metabolism, and salt-sensitive hypertension.Medical sequencing at the extremes of human body mass.Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesityFunctions of DPLIY motif and helix 8 of human melanocortin-3 receptor.New targets to treat obesity and the metabolic syndrome.Functional characterization of nine novel naturally occurring human melanocortin-3 receptor mutations.A mouse model for a partially inactive obesity-associated human MC3R variant.Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study.Neural melanocortin receptors in obesity and related metabolic disorders.Effects of Melanocortin 3 and 4 Receptor Deficiency on Energy Homeostasis in Rats.Melanocortin 3 receptor gene and melanocortin 4 receptor gene mutations: the Asian Perspective.Polymorphisms and mutations in the melanocortin-3 receptor and their relation to human obesity.Biased signaling at neural melanocortin receptors in regulation of energy homeostasis.Functions of acidic transmembrane residues in human melanocortin-3 receptor binding and activation.The Val81 missense mutation of the melanocortin 3 receptor gene, but not the 1908c/T nucleotide polymorphism in lamin A/C gene, is associated with hyperleptinemia and hyperinsulinemia in obese Greek caucasians.Identification of the downstream targets of SIM1 and ARNT2, a pair of transcription factors essential for neuroendocrine cell differentiation.Functional characterization and pharmacological rescue of melanocortin-4 receptor mutations identified from obese patients.Identification of the translation start site of the human melanocortin 3 receptor.RAR-related orphan receptor A isoform 1 (RORa1) is disrupted by a balanced translocation t(4;15)(q22.3;q21.3) associated with severe obesity.Common melanocortin-3 receptor variants are not associated with obesity, although rs3746619 does influence weight in obese individuals.Altered feeding and body weight following melanocortin administration to the ventral tegmental area in adult rats.Altered sucrose self-administration following injection of melanocortin receptor agonists and antagonists into the ventral tegmental area.Neuroendocrine regulation of eating behavior.Genetic Aspects of Obesity.Pharmacological Chaperones: Potential for the Treatment of Hereditary Diseases Caused by Mutations in G Protein-Coupled ReceptorsFurther Evidence For the Role ofENPP1in Obesity: Association With Morbid Obesity in FinnsThe Human Obesity Gene Map: The 2004 UpdatePrevalence of rare MC3R variants in obese cases and lean controls
P2860
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P2860
A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity
@ast
A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity
@en
A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity
@nl
type
label
A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity
@ast
A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity
@en
A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity
@nl
prefLabel
A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity
@ast
A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity
@en
A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity
@nl
P2093
P3181
P1476
A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity
@en
P2093
Kah-Yin Loke
Larry Kok-Seng Poh
Yung-Seng Lee
P304
P3181
P356
10.1210/JC.87.3.1423
10.1210/JCEM.87.3.8461
P407
P577
2002-03-01T00:00:00Z