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Mutations in SYNGAP1 in autosomal nonsyndromic mental retardationRole of Unc51.1 and its binding partners in CNS axon outgrowthRapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.SynGAP isoforms exert opposing effects on synaptic strengthMultivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2SynGAP moves out of the core of the postsynaptic density upon depolarizationThe MUPP1-SynGAPalpha protein complex does not mediate activity-induced LTPNIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity.Association of membrane rafts and postsynaptic density: proteomics, biochemical, and ultrastructural analyses.Targeting of calcium/calmodulin-dependent protein kinase II.A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain 'Slots' in the postsynaptic densityBAALC 1-6-8 protein is targeted to postsynaptic lipid rafts by its N-terminal myristoylation and palmitoylation, and interacts with alpha, but not beta, subunit of Ca/calmodulin-dependent protein kinase II.Differential modulation of Ca2+/calmodulin-dependent protein kinase II activity by regulated interactions with N-methyl-D-aspartate receptor NR2B subunits and alpha-actinin.Ca2+/calmodulin-dependent protein kinase IIalpha clusters are associated with stable lipid rafts and their formation traps PSD-95.Mutations in SYNGAP1 cause intellectual disability, autism, and a specific form of epilepsy by inducing haploinsufficiency.Species-conserved SYNGAP1 phenotypes associated with neurodevelopmental disorders.
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Characterization of a novel synGAP isoform, synGAP-beta
@ast
Characterization of a novel synGAP isoform, synGAP-beta
@en
Characterization of a novel synGAP isoform, synGAP-beta
@nl
type
label
Characterization of a novel synGAP isoform, synGAP-beta
@ast
Characterization of a novel synGAP isoform, synGAP-beta
@en
Characterization of a novel synGAP isoform, synGAP-beta
@nl
prefLabel
Characterization of a novel synGAP isoform, synGAP-beta
@ast
Characterization of a novel synGAP isoform, synGAP-beta
@en
Characterization of a novel synGAP isoform, synGAP-beta
@nl
P2093
P2860
P3181
P356
P1476
Characterization of a novel synGAP isoform, synGAP-beta
@en
P2093
K Nakayama
T Furihata
P2860
P304
P3181
P356
10.1074/JBC.M010744200
P407
P577
2001-06-15T00:00:00Z