Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2)
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Functional properties and genomics of glucose transportersPharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agentsRenal sodium glucose cotransporter 2 inhibitors as a novel therapeutic approach to treatment of type 2 diabetes: Clinical data and mechanism of actionActive sugar transport in health and diseaseTwenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletionDrug off-target effects predicted using structural analysis in the context of a metabolic network modelPygo1 and Pygo2 roles in Wnt signaling in mammalian kidney developmentInfluence of Familial Renal Glycosuria Due to Mutations in the SLC5A2 Gene on Changes in Glucose Tolerance over TimeHuman genetics as a model for target validation: finding new therapies for diabetes.Sodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides.Organization of the pronephric kidney revealed by large-scale gene expression mapping.Dapagliflozin for the treatment of type 2 diabetes.SGLT2 mediates glucose reabsorption in the early proximal tubule.Dapagliflozin efficacy and safety: a perspective review.SHR3824, a novel selective inhibitor of renal sodium glucose cotransporter 2, exhibits antidiabetic efficacy in rodent models.The iodide-transport-defect-causing mutation R124H: a δ-amino group at position 124 is critical for maturation and trafficking of the Na+/I- symporter.Novel SLC5A2 mutation contributes to familial renal glucosuria: Abnormal expression in renal tissues.Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes.A recurrent deletion in the SLC5A2 gene including the intron 7 branch site responsible for familial renal glucosuria.SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice.Dapagliflozin: where does it fit in the treatment of type 2 diabetes?Sodium-glucose transport: role in diabetes mellitus and potential clinical implications.Diabetes area participation analysis: a review of companies and targets described in the 2008 - 2010 patent literature.Effects of SGLT2 inhibitors on cardiovascular outcomes.Dapagliflozin: a novel sodium-glucose cotransporter type 2 inhibitor for the treatment of type 2 diabetes mellitus.SGLT2 inhibitors: a promising new therapeutic option for treatment of type 2 diabetes mellitus.Pathophysiology of the diabetic kidney.SGLT-2 Inhibitors in Heart Failure: Implications for the Kidneys.Abnormal expression and dysfunction of novel SGLT2 mutations identified in familial renal glucosuria patients.Pharmacodynamic model of sodium-glucose transporter 2 (SGLT2) inhibition: implications for quantitative translational pharmacology.Euglycemic Diabetic Ketoacidosis With Prolonged Glucosuria Associated With the Sodium-Glucose Cotransporter-2 Canagliflozin.Clinical and genetic analysis in a patient with primary renal glucosuria: Identification of a novel mutation in the SLC5A2 gene.Multiple-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy overweight and obese subjects: a randomized double-blind study.Role of genetic variation in the human sodium-glucose cotransporter 2 gene (SGLT2) in glucose homeostasis.Salt-Losing Tubulopathies in Children: What's New, What's Controversial?Emerging roles of SGLT2 inhibitors in obesity and insulin resistance: Focus on fat browning and macrophage polarization.Defective SLC5A2 does not cotransport Glc and Na+ from extracellular region to cytosolPharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo.Novel SLC5A2 variants contribute to renal glucosuria in Chinese families: abnormal expression and dysfunction of variant SLC5A2.Familial renal glucosuria: a clinicogenetic study of 23 additional cases.
P2860
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P2860
Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2)
description
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im Dezember 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: December 2002)
@en
vedecký článok (publikovaný 2002-12)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd in 2002-12)
@nl
наукова стаття, опублікована в грудні 2002
@uk
مقالة علمية (نشرت في ديسمبر 2002)
@ar
name
Autosomal recessive renal gluc ...... glucose cotransporter (SGLT2)
@ast
Autosomal recessive renal gluc ...... glucose cotransporter (SGLT2)
@en
Autosomal recessive renal gluc ...... glucose cotransporter (SGLT2)
@nl
type
label
Autosomal recessive renal gluc ...... glucose cotransporter (SGLT2)
@ast
Autosomal recessive renal gluc ...... glucose cotransporter (SGLT2)
@en
Autosomal recessive renal gluc ...... glucose cotransporter (SGLT2)
@nl
prefLabel
Autosomal recessive renal gluc ...... glucose cotransporter (SGLT2)
@ast
Autosomal recessive renal gluc ...... glucose cotransporter (SGLT2)
@en
Autosomal recessive renal gluc ...... glucose cotransporter (SGLT2)
@nl
P2093
P3181
P1433
P1476
Autosomal recessive renal gluc ...... glucose cotransporter (SGLT2)
@en
P2093
L P van den Heuvel
M Willemsen
P2888
P3181
P356
10.1007/S00439-002-0820-5
P407
P577
2002-12-01T00:00:00Z
P6179
1002363097