Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE
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PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland developmentRecruitment and activation of PLCgamma1 in T cells: a new insight into old domainsAkt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factorNetrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5BNeuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidasePLC-gamma1 and Rac1 coregulate EGF-induced cytoskeleton remodeling and cell migrationPhospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1BPhosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalingsPIKE-A is amplified in human cancers and prevents apoptosis by up-regulating AktRIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cellsThe centaurin gamma-1 GTPase-like domain functions as an NTPasePIKE GTPase signaling and functionThe roles of PIKE in tumorigenesisTyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangementsCEACAM1 regulates TIM-3-mediated tolerance and exhaustionHonokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivoPI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosisPIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasionPIKE-mediated PI3-kinase activity is required for AMPA receptor surface expressionc-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBPRegulation of EGF-induced phospholipase C-gamma1 translocation and activation by its SH2 and PH domainsPIKE mediates EGFR proliferative signaling in squamous cell carcinoma cells.The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis.Phospholipase C-gamma1 is involved in signaling the activation by high NaCl of the osmoprotective transcription factor TonEBP/OREBP.Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex.Structural basis for recognition of the T cell adaptor protein SLP-76 by the SH3 domain of phospholipase Cgamma1Src homology domains in phospholipase C-gamma1 mediate its anti-apoptotic action through regulating the enzymatic activity.Structural characterization of the split pleckstrin homology domain in phospholipase C-gamma1 and its interaction with TRPC3.Phospholipase C-gamma contains introns shared by src homology 2 domains in many unrelated proteins.Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance.Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis.Insulin receptor-mediated signaling via phospholipase C-γ regulates growth and differentiation in DrosophilaHigh NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization.Distinct phospholipase C-gamma-dependent signaling pathways in the Drosophila eye and wing are revealed by a new small wing allele.Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation.Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner.Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survivalInhibition of 4-nitroquinoline-1-oxide-induced oral carcinogenesis by dietary calcium.Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC-γ1 and PIKE are associated with aggressiveness of oral squamous cell carcinoma.Biochemical and cellular implications of a dual lipase-GEF function of phospholipase D2 (PLD2).
P2860
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P2860
Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE
description
2002 nî lūn-bûn
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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Phospholipase C gamma 1 is a p ...... or for the nuclear GTPase PIKE
@ast
Phospholipase C gamma 1 is a p ...... or for the nuclear GTPase PIKE
@en
Phospholipase C gamma 1 is a p ...... or for the nuclear GTPase PIKE
@nl
type
label
Phospholipase C gamma 1 is a p ...... or for the nuclear GTPase PIKE
@ast
Phospholipase C gamma 1 is a p ...... or for the nuclear GTPase PIKE
@en
Phospholipase C gamma 1 is a p ...... or for the nuclear GTPase PIKE
@nl
prefLabel
Phospholipase C gamma 1 is a p ...... or for the nuclear GTPase PIKE
@ast
Phospholipase C gamma 1 is a p ...... or for the nuclear GTPase PIKE
@en
Phospholipase C gamma 1 is a p ...... or for the nuclear GTPase PIKE
@nl
P2093
P2860
P50
P356
P1433
P1476
Phospholipase C gamma 1 is a p ...... or for the nuclear GTPase PIKE
@en
P2093
Bahman Aghdasi
Frederick Y Wu
Hongbo R Luo
Jenny J Hong
John L Moriarity
Keqiang Ye
Sun Sik Bae
P2860
P2888
P356
10.1038/415541A
P407
P577
2002-01-31T00:00:00Z
P5875
P6179
1037902201