ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation
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TRKing down an old oncogene in a new era of targeted therapyMicrodeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor.The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-beta signaling by inactivating the TGF-beta type II receptorMutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity.Expression of ETV6-NTRK in classical, cellular and mixed subtypes of congenital mesoblastic nephroma.Exploring Mouse Protein Function via Multiple Approaches.Transcriptome correlation analysis identifies two unique craniosynostosis subtypes associated with IRS1 activation.Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers.Customizing the targeting of IGF-1 receptor.Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy.Adenovirus fiber shaft contains a trimerization element that supports peptide fusion for targeted gene delivery.Transcriptome sequencing identifies ETV6-NTRK3 as a gene fusion involved in GIST.Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Mutual interaction and reciprocal down-regulation between c-met and insulin receptor substrate-1.A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation.Leptocarpin Suppresses Proliferation, Migration, and Invasion of Human Osteosarcoma by Targeting Type-1 Insulin-Like Growth Factor Receptor (IGF-1R).Mutation of the salt bridge-forming residues in the ETV6-SAM domain interface blocks ETV6-NTRK3-induced cellular transformation.Genomic profiling of breast secretory carcinomas reveals distinct genetics from other breast cancers and similarity to mammary analog secretory carcinomas.The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase.EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases.Targeting the Oncogenic Transcriptional Regulator MYB in Adenoid Cystic Carcinoma by Inhibition of IGF1R/AKT Signaling.Transcription factor TIP27 regulates glucose homeostasis and insulin sensitivity in a PI3-kinase/Akt-dependent manner in mice.The crucial role of multiomic approach in cancer research and clinically relevant outcomes.A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation.Signaling by NTRK3 (TRKC)Activated NTRK3 signals through PI3K
P2860
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P2860
ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
ETV6-NTRK3 transformation requ ...... IRS-1 tyrosine phosphorylation
@ast
ETV6-NTRK3 transformation requ ...... IRS-1 tyrosine phosphorylation
@en
ETV6-NTRK3 transformation requ ...... IRS-1 tyrosine phosphorylation
@nl
type
label
ETV6-NTRK3 transformation requ ...... IRS-1 tyrosine phosphorylation
@ast
ETV6-NTRK3 transformation requ ...... IRS-1 tyrosine phosphorylation
@en
ETV6-NTRK3 transformation requ ...... IRS-1 tyrosine phosphorylation
@nl
prefLabel
ETV6-NTRK3 transformation requ ...... IRS-1 tyrosine phosphorylation
@ast
ETV6-NTRK3 transformation requ ...... IRS-1 tyrosine phosphorylation
@en
ETV6-NTRK3 transformation requ ...... IRS-1 tyrosine phosphorylation
@nl
P2093
P2860
P356
P1433
P1476
ETV6-NTRK3 transformation requ ...... IRS-1 tyrosine phosphorylation
@en
P2093
Cheri Deal
Cristina E Tognon
Kevin B Morrison
Mathew J Garnett
Poul H B Sorensen
P2860
P2888
P304
P356
10.1038/SJ.ONC.1205669
P407
P577
2002-08-22T00:00:00Z
P5875
P6179
1006254844