Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin
about
Design, synthesis, and pharmacological evaluation of haloperidol derivatives as novel potent calcium channel blockers with vasodilator activityTherapeutic applications of the gaseous mediators carbon monoxide and hydrogen sulfide.In vitro evaluation of novel N-acetylalaninate prodrugs that selectively induce apoptosis in prostate cancer cellsA novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties.NOSH-Aspirin: A Novel Nitric Oxide-Hydrogen Sulfide-Releasing Hybrid: A New Class of Anti-inflammatory Pharmaceuticals.Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelationNCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisplatin by depletion of cellular thiols.The Antineoplastic Effect of Nitric Oxide-Donating Acetylsalicylic Acid (NO-ASA) in Chronic Lymphocytic Leukemia (CLL) Cells is Highly Dependent on its Positional Isomerism.NO-donating aspirin inhibits angiogenesis by suppressing VEGF expression in HT-29 human colon cancer mouse xenograftsNO-donating NSAIDs and cancer: an overview with a note on whether NO is required for their action.Nitric oxide and cancer therapy: the emperor has NO clothesModulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct formation.Synthesis and chemical and biological comparison of nitroxyl- and nitric oxide-releasing diazeniumdiolate-based aspirin derivativesAspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model.Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimerasProdrugs of nonsteroidal anti-inflammatory drugs (NSAIDs), more than meets the eye: a critical review.Amplification of oxidative stress by a dual stimuli-responsive hybrid drug enhances cancer cell death.Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach.Flurbiprofen benzyl nitrate (NBS-242) inhibits the growth of A-431 human epidermoid carcinoma cells and targets β-catenin.Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide.Structure-activity relationship study of novel anticancer aspirin-based compounds.Nitrates and NO-NSAIDs in cancer chemoprevention and therapy: in vitro evidence querying the NO donor functionalityInhibition of Murine Systemic Leishmaniasis by Acetyl Salicylic Acid via Nitric Oxide ImmunomodulationThe differential cell signaling effects of two positional isomers of the anticancer NO-donating aspirin.Regio- and chemoselective palladium-catalyzed benzylallylation of activated olefins: the remarkable effect of palladium nanoparticles.Therapeutic Vesicular Nanoreactors with Tumor-Specific Activation and Self-Destruction for Synergistic Tumor Ablation.The dichotomous role of H2S in cancer cell biology? Déjà vu all over again.Biocompatible Boron-Containing Prodrugs of Belinostat for the Potential Treatment of Solid Tumors.Prodrugs Bioactivated to Quinones Target NF-κB and Multiple Protein Networks: Identification of the Quinonome.Aspirination of α-Aminoalcohol (Sarpogrelate M1).
P2860
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P2860
Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Chemical insights in the conce ...... t not nitric oxide nor aspirin
@ast
Chemical insights in the conce ...... t not nitric oxide nor aspirin
@en
Chemical insights in the conce ...... t not nitric oxide nor aspirin
@nl
type
label
Chemical insights in the conce ...... t not nitric oxide nor aspirin
@ast
Chemical insights in the conce ...... t not nitric oxide nor aspirin
@en
Chemical insights in the conce ...... t not nitric oxide nor aspirin
@nl
prefLabel
Chemical insights in the conce ...... t not nitric oxide nor aspirin
@ast
Chemical insights in the conce ...... t not nitric oxide nor aspirin
@en
Chemical insights in the conce ...... t not nitric oxide nor aspirin
@nl
P2093
P356
P1476
Chemical insights in the conce ...... t not nitric oxide nor aspirin
@en
P2093
Aldo Jongejan
Carina Bos
Dick Richel
Iwan J P de Esch
Jan Paul Medema
Maikel Wijtmans
Martine J Smit
Niels Hulsman
P304
P356
10.1021/JM061371E
P407
P577
2007-05-17T00:00:00Z