Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice - Wikidata - awgldk - TriplyDB

Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice

Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice

http://www.wikidata.org/entity/Q28235182

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Atypical angiopoietin-like protein that regulates ANGPTL3 GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4 Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking Intronic cis-regulatory modules mediate tissue-specific and microbial control of angptl4/fiaf transcription The angiopoietin-like proteins ANGPTL3 and ANGPTL4 inhibit lipoprotein lipase activity through distinct mechanisms Angiopoietin-like 4 stimulates STAT3-mediated iNOS expression and enhances angiogenesis to accelerate wound healing in diabetic mice Angiopoietin-like 4: a decade of research Angiopoietin-like protein 4: health effects, modulating agents and structure-function relationships Angiopoietin-like protein 4 inhibition of lipoprotein lipase: evidence for reversible complex formation The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice.Induction of ANGPTL4 expression in human airway smooth muscle cells by PMA through activation of PKC and MAPK pathways.Gene expression profiling of subcutaneous adipose tissue in morbid obesity using a focused microarray: distinct expression of cell-cycle- and differentiation-related genes A lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase.Angiopoietin-like 4 (ANGPTL4) gene polymorphisms and risk of brain arteriovenous malformations.Genetics of coronary artery disease: discovery, biology and clinical translation.Regulation of angiopoietin-like protein 4 production during and after exercise.Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity.Characterization of a Novel Intestinal Glycerol-3-phosphate Acyltransferase Pathway and Its Role in Lipid Homeostasis Effect of chronic intermittent hypoxia on triglyceride uptake in different tissues.Angiopoietin-like 4 (Angptl4): A glucocorticoid-dependent gatekeeper of fatty acid flux during fasting.Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.The Arg59Trp variant in ANGPTL8 (betatrophin) is associated with total and HDL-cholesterol in American Indians and Mexican Americans and differentially affects cleavage of ANGPTL3.Enhanced angiogenesis in obesity and in response to PPARgamma activators through adipocyte VEGF and ANGPTL4 production.Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque.ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression.Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4.Variation in ANGPTL4 and risk of coronary heart disease: the Atherosclerosis Risk in Communities Study Adipose tissue angiogenesis: impact on obesity and type-2 diabetes.Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin.Angiopoietin-like proteins 3, 4 and 8: regulating lipid metabolism and providing new hope for metabolic syndrome.Emerging strategies of targeting lipoprotein lipase for metabolic and cardiovascular diseases.Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver.Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes.Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting.A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization.

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Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice

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2007 nî lūn-bûn

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2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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Gwenn Hansen

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P2860

Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice

Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN

Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation

The gut microbiota as an environmental factor that regulates fat storage

Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene

ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase

Differential regulation and properties of angiopoietin-like proteins 3 and 4

Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention

Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase

Construction of gene targeting vectors from lambda KOS genomic libraries.

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