AMD3100 is a CXCR7 ligand with allosteric agonist properties - Wikidata - awgldk - TriplyDB

AMD3100 is a CXCR7 ligand with allosteric agonist properties

AMD3100 is a CXCR7 ligand with allosteric agonist properties

http://www.wikidata.org/entity/Q28236927

about

Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis.Carboxy-terminus of CXCR7 regulates receptor localization and function Ubiquitination of CXCR7 controls receptor trafficking Novel therapeutic targets for pancreatic cancer CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7 Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives MIF and CXCL12 in Cardiovascular Diseases: Functional Differences and Similarities Chemokines and their receptors in Atherosclerosis Development of a unique small molecule modulator of CXCR4 CXCR7 functions as a scavenger for CXCL12 and CXCL11 Identification of anti-malarial compounds as novel antagonists to chemokine receptor CXCR4 in pancreatic cancer cells Quantification of ligand binding to G-protein coupled receptors on cell membranes by ellipsometry The CXCR4 mutations in WHIM syndrome impair the stability of the T-cell immunologic synapse The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice.CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment.CXCR7 controls competition for recruitment of β-arrestin 2 in cells expressing both CXCR4 and CXCR7.Expression and function of CXCL12/CXCR4 in rat urinary bladder with cyclophosphamide-induced cystitis Emerging concepts and approaches for chemokine-receptor drug discovery.Inhibition of CXCL12/CXCR4 axis as a potential targeted therapy of advanced gastric carcinoma Chemokine receptor CXCR7 regulates the invasion, angiogenesis and tumor growth of human hepatocellular carcinoma cells.Chemokine receptor oligomerization and allostery.Effects of the chemokine CXCL12 and combined internalization of its receptors CXCR4 and CXCR7 in human MCF-7 breast cancer cells.Inhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinib Chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3 regulate vascular α₁-adrenergic receptor function.Fragment-based optimization of small molecule CXCL12 inhibitors for antagonizing the CXCL12/CXCR4 interaction.Imaging ligand-dependent activation of CXCR7.Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: molecular modeling and experimental validation.CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?Aberrant proliferation in CXCR7+ endothelial cells via degradation of the retinoblastoma protein.SDF-1α secreted by human CD133-derived multipotent stromal cells promotes neural progenitor cell survival through CXCR7 Blocking SDF-1α/CXCR4 downregulates PDGF-B and inhibits bone marrow-derived pericyte differentiation and tumor vascular expansion in Ewing tumors.CXCR4 Antagonists: A Screening Strategy for Identification of Functionally Selective Ligands.Inhibition of the CXCL12/CXCR4 chemokine axis with AMD3100, a CXCR4 small molecule inhibitor, worsens murine hepatic injury.CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph.CXC chemokine ligand 12 protects pancreatic β-cells from necrosis through Akt kinase-mediated modulation of poly(ADP-ribose) polymerase-1 activity.CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration.AMD3100-mediated production of interleukin-1 from mesenchymal stem cells is key to chemosensitivity of breast cancer cells.p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1α-mediated down-regulation of CXCL12.Treatment with AMD3100 attenuates the microglial response and improves outcome after experimental stroke

P2860

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P2860

AMD3100 is a CXCR7 ligand with allosteric agonist properties

http://www.wikidata.org/entity/Q28236927

description

2009 nî lūn-bûn

@nan

2009 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

AMD3100 is a CXCR7 ligand with allosteric agonist properties

@ast

AMD3100 is a CXCR7 ligand with allosteric agonist properties

@en

AMD3100 is a CXCR7 ligand with allosteric agonist properties

@nl

type

label

AMD3100 is a CXCR7 ligand with allosteric agonist properties

@ast

AMD3100 is a CXCR7 ligand with allosteric agonist properties

@en

AMD3100 is a CXCR7 ligand with allosteric agonist properties

@nl

prefLabel

AMD3100 is a CXCR7 ligand with allosteric agonist properties

@ast

AMD3100 is a CXCR7 ligand with allosteric agonist properties

@en

AMD3100 is a CXCR7 ligand with allosteric agonist properties

@nl

P1433

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P1433

Molecular Pharmacology

P1476

AMD3100 is a CXCR7 ligand with allosteric agonist properties

@en

P2093

Brian J Limberg

http://www.w3.org/2001/XMLSchema#string

Jan S Rosenbaum

http://www.w3.org/2001/XMLSchema#string

Nikolaus Heveker

http://www.w3.org/2001/XMLSchema#string

Stéphanie Gravel

http://www.w3.org/2001/XMLSchema#string

Yamina A Berchiche

http://www.w3.org/2001/XMLSchema#string

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1240-7

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scholarly article

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3106626

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10.1124/MOL.108.053389

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P433

5

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75

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Irina Kalatskaya

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2009-05-01T00:00:00Z

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24171606

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P698

19255243

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