Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor
about
The G53D mutation in Kir6.2 (KCNJ11) is associated with neonatal diabetes and motor dysfunction in adulthood that is improved with sulfonylurea therapy.Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological propertiesMolecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological featuresHomology modeling and molecular dynamics simulation studies of an inward rectifier potassium channelNoble gas xenon is a novel adenosine triphosphate-sensitive potassium channel openerHow ATP inhibits the open K(ATP) channelDrugs acting on SUR1 to treat CNS ischemia and traumaA mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetesABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gatingPhorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of KATP channelsRunning out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channelsHyperinsulinemic Hypoglycemia - The Molecular MechanismsThe Nucleotide-Binding Sites of SUR1: A Mechanistic ModelMolecular action of sulphonylureas on KATP channels: a real partnership between drugs and nucleotidesTargeting microglial K(ATP) channels to treat neurodegenerative diseases: a mitochondrial issueCrystal structure of full-length KcsA in its closed conformationA heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes.Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel.Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's diseaseMapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3Potassium channel regulation.The carboxyl termini of K(ATP) channels bind nucleotidesIdentification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channelsAssembly limits the pharmacological complexity of ATP-sensitive potassium channelsToward understanding the assembly and structure of KATP channelsMechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoAMechanism of terfenadine block of ATP-sensitive K(+) channelsATP interaction with the open state of the K(ATP) channel.Interaction of stilbene disulphonates with cloned K(ATP) channelsSynthesis and characterization of a quinolinonic compound activating ATP-sensitive K(+) channels in endocrine and smooth muscle tissuesEffects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channelDual action of ZD6169, a novel K(+) channel opener, on ATP-sensitive K(+) channels in pig urethral myocytesGlimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channelsSynthesis and characterization of a novel tritiated KATP channel opener with a benzopyran structureCreatine kinase is physically associated with the cardiac ATP-sensitive K+ channel in vivoThe effects of flecainide on ATP-sensitive K(+) channels in pig urethral myocytesNADH shuttle system regulates K(ATP) channel-dependent pathway and steps distal to cytosolic Ca(2+) concentration elevation in glucose-induced insulin secretionβ2-Adrenergic ion-channel coupled receptors as conformational motion detectorsEvidence for direct physical association between a K+ channel (Kir6.2) and an ATP-binding cassette protein (SUR1) which affects cellular distribution and kinetic behavior of an ATP-sensitive K+ channel
P2860
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P2860
Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor
description
1997 nî lūn-bûn
@nan
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Truncation of Kir6.2 produces ...... of the sulphonylurea receptor
@ast
Truncation of Kir6.2 produces ...... of the sulphonylurea receptor
@en
Truncation of Kir6.2 produces ...... of the sulphonylurea receptor
@nl
type
label
Truncation of Kir6.2 produces ...... of the sulphonylurea receptor
@ast
Truncation of Kir6.2 produces ...... of the sulphonylurea receptor
@en
Truncation of Kir6.2 produces ...... of the sulphonylurea receptor
@nl
prefLabel
Truncation of Kir6.2 produces ...... of the sulphonylurea receptor
@ast
Truncation of Kir6.2 produces ...... of the sulphonylurea receptor
@en
Truncation of Kir6.2 produces ...... of the sulphonylurea receptor
@nl
P50
P3181
P356
P1433
P1476
Truncation of Kir6.2 produces ...... of the sulphonylurea receptor
@en
P2093
P2888
P304
P3181
P356
10.1038/387179A0
P407
P577
1997-05-01T00:00:00Z
P5875
P6179
1006963985