Thymosin beta 4 binds actin in an extended conformation and contacts both the barbed and pointed ends
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Thymosin-beta(4) changes the conformation and dynamics of actin monomersFrom the first to the second domain of gelsolin: a common path on the surface of actin?How a single residue in individual β-thymosin/WH2 domains controls their functions in actin assemblyMouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domainControl of actin dynamics by proteins made of beta-thymosin repeats: the actobindin family.A phage display-based method for determination of relative affinities of mutants. Application of the actin-binding motifs in thymosin beta 4 and the villin headpiece.Thymosin beta(4) serves as a glutaminyl substrate of transglutaminase. Labeling with fluorescent dansylcadaverine does not abolish interaction with G-actin.Different thymosin Beta 4 immunoreactivity in foetal and adult gastrointestinal tractWH2 domain: a small, versatile adapter for actin monomers.Mammalian tropomodulins nucleate actin polymerization via their actin monomer binding and filament pointed end-capping activities.Thymosin beta4 induces a conformational change in actin monomers.Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization.Models of the actin-bound forms of the beta-thymosins.The beta-thymosin/WH2 fold: multifunctionality and structure.Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin beta is the true human homologue of rat thymosin beta15.Structure, function, and evolution of the beta-thymosin/WH2 (WASP-Homology2) actin-binding module.Integrated transcriptome analysis of the cellular mechanisms associated with Ha-ras-dependent malignant transformation of the human breast epithelial MCF7 cell line.The actin cytoskeleton as a sensor and mediator of apoptosisIdentification and characterization of the actin-binding motif of phostensinWidely distributed residues in thymosin beta4 are critical for actin bindingSpatial coordination of actin polymerization and ILK-Akt2 activity during endothelial cell migration.TetraThymosinbeta is required for actin dynamics in Caenorhabditis elegans and acts via functionally different actin-binding repeats.Intrinsic structural disorder in cytoskeletal proteins.Structural features and interfacial properties of WH2, β-thymosin domains and other intrinsically disordered domains in the regulation of actin cytoskeleton dynamics.Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration.Structural basis of actin sequestration by thymosin-beta4: implications for WH2 proteins.Use of fluorescently labelled deoxyribonuclease I to spatially measure G-actin levels in migrating and non-migrating cells.Identification of PDGF-BB binding to thymosin β4 by chemical cross-linking.EzrA prevents aberrant cell division by modulating assembly of the cytoskeletal protein FtsZProlyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP.Early and progressive accumulation of reactive microglia in the Huntington disease brain.Actin filament cross-linking by MARCKS: characterization of two actin-binding sites within the phosphorylation site domain.Downregulation of profilin with antisense oligodeoxynucleotides inhibits force development during stimulation of smooth muscle.Thymosin β4 and tissue transglutaminase. Molecular characterization of cyclic thymosin β4.Coupling of folding and binding of thymosin beta4 upon interaction with monomeric actin monitored by nuclear magnetic resonance.Reconsidering an active role for G-actin in cytoskeletal regulation.The intrinsically disordered Tarp protein from chlamydia binds actin with a partially preformed helix.Beta-thymosins from marine invertebrates: primary structure and interaction with actin.Protein moonlighting: what is it, and why is it important?Influence of the N terminus and the actin-binding motif of thymosin beta4 on its interaction with G-actin.
P2860
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P2860
Thymosin beta 4 binds actin in an extended conformation and contacts both the barbed and pointed ends
description
1997 nî lūn-bûn
@nan
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Thymosin beta 4 binds actin in ...... th the barbed and pointed ends
@ast
Thymosin beta 4 binds actin in ...... th the barbed and pointed ends
@en
type
label
Thymosin beta 4 binds actin in ...... th the barbed and pointed ends
@ast
Thymosin beta 4 binds actin in ...... th the barbed and pointed ends
@en
altLabel
Thymosin β 4 Binds Actin in an ...... the Barbed and Pointed Ends †
@en
prefLabel
Thymosin beta 4 binds actin in ...... th the barbed and pointed ends
@ast
Thymosin beta 4 binds actin in ...... th the barbed and pointed ends
@en
P356
P1433
P1476
Thymosin beta 4 binds actin in ...... th the barbed and pointed ends
@en
Thymosin β 4 Binds Actin in an ...... the Barbed and Pointed Ends †
@en
P2093
Daniel Safer
Marshall Elzinga
P304
P356
10.1021/BI970185V
P407
P577
1997-05-01T00:00:00Z
1997-05-13T00:00:00Z