Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme
about
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcriptionRegulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stressLysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancerCrystal structures of human SIRT3 displaying substrate-induced conformational changesAcylation of Biomolecules in Prokaryotes: a Widespread Strategy for the Control of Biological Function and Metabolic StressStructural basis for sirtuin activity and inhibitionInsulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 EnzymesStructural Insights into Intermediate Steps in the Sir2 Deacetylation ReactionEx-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanismStructural and Functional Analysis of Human SIRT1p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum ConceptOxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutaseSIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growthSirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's diseaseBiochemical and mutational analysis of a novel nicotinamidase from Oceanobacillus iheyensis HTE831Computational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicalsGenetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of Huntington's diseaseSelective Sirt2 inhibition by ligand-induced rearrangement of the active site.Insights into Lysine Deacetylation of Natively Folded Substrate Proteins by Sirtuins.Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectivesCatastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.Fusaric Acid Induces DNA Damage and Post-Translational Modifications of p53 in Human Hepatocellular Carcinoma (HepG2 ) Cells.Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation.Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activityHuman sirt-1: molecular modeling and structure-function relationships of an unordered protein.Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.Sirtinol promotes PEPCK1 degradation and inhibits gluconeogenesis by inhibiting deacetylase SIRT2.Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation.SIRT3 substrate specificity determined by peptide arrays and machine learning.Reconstruction of pathway modification induced by nicotinamide using multi-omic network analyses in triple negative breast cancer.Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney diseaseAdiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling.Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors.Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.Metabolic Effects of Known and Novel HDAC and SIRT Inhibitors in Glioblastomas Independently or Combined with TemozolomideSirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells.Insight the C-site pocket conformational changes responsible for sirtuin 2 activity using molecular dynamics simulations.Proinflammatory stimuli control N-acylphosphatidylethanolamine-specific phospholipase D expression in macrophages.
P2860
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P2860
Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme
description
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im März 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 18 March 2005)
@en
vedecký článok (publikovaný 2005/03/18)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/03/18)
@nl
наукова стаття, опублікована в березні 2005
@uk
مقالة علمية (نشرت في 18-3-2005)
@ar
name
Mechanism of sirtuin inhibitio ...... e specificity of a Sir2 enzyme
@ast
Mechanism of sirtuin inhibitio ...... e specificity of a Sir2 enzyme
@en
Mechanism of sirtuin inhibitio ...... e specificity of a Sir2 enzyme
@nl
type
label
Mechanism of sirtuin inhibitio ...... e specificity of a Sir2 enzyme
@ast
Mechanism of sirtuin inhibitio ...... e specificity of a Sir2 enzyme
@en
Mechanism of sirtuin inhibitio ...... e specificity of a Sir2 enzyme
@nl
prefLabel
Mechanism of sirtuin inhibitio ...... e specificity of a Sir2 enzyme
@ast
Mechanism of sirtuin inhibitio ...... e specificity of a Sir2 enzyme
@en
Mechanism of sirtuin inhibitio ...... e specificity of a Sir2 enzyme
@nl
P2093
P50
P1433
P1476
Mechanism of sirtuin inhibitio ...... e specificity of a Sir2 enzyme
@en
P2093
Cynthia Wolberger
José L Avalos
Katherine M Bever
P304
P356
10.1016/J.MOLCEL.2005.02.022
P407
P577
2005-03-01T00:00:00Z