Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID - Wikidata - awgldk - TriplyDB

Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

http://www.wikidata.org/entity/Q28241595

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Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3)A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9 Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain Two mutational hotspots in the interleukin-2 receptor gamma chain gene causing human X-linked severe combined immunodeficiency The molecular pathology of primary immunodeficiencies Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.Inborn errors of the development of human natural killer cells Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9 CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex Mutations in genes required for T-cell development: IL7R, CD45, IL2RG, JAK3, RAG1, RAG2, ARTEMIS, and ADA and severe combined immunodeficiency: HuGE review Expression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cells Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinases A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes Jak3 negatively regulates dendritic-cell cytokine production and survival Distinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversity Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transduction Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15 Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway Heteromerization of the c Chain with the Interleukin-9 Receptor Subunit Leads to STAT Activation and Prevention of Apoptosis Severe combined immunodeficiencies (SCID)Binding of src-like kinases to the beta-subunit of the interleukin-3 receptor.Interleukin-4 Expressed By Neoplastic Cells Provokes an Anti-Metastatic Myeloid Immune Response.IL-2 independent transformation of a unique human T cell line, TY8-3, and its subclones by HTLV-I and -II.JAK and MPL mutations in myeloid malignancies.The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes

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P2860

Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

http://www.wikidata.org/entity/Q28241595

description

1994 nî lūn-bûn

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1994 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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1994 թվականի նոյեմբերին հրատարակված գիտական հոդված

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1994年の論文

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1994年論文

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1994年論文

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1994年論文

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1994年論文

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1994年論文

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1994年论文

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Interaction of IL-2R beta and ...... mplications for XSCID and XCID

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Interaction of IL-2R beta and ...... mplications for XSCID and XCID

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Interaction of IL-2R beta and ...... mplications for XSCID and XCID

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Interaction of IL-2R beta and ...... mplications for XSCID and XCID

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Interaction of IL-2R beta and ...... mplications for XSCID and XCID

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Interaction of IL-2R beta and ...... mplications for XSCID and XCID

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Interaction of IL-2R beta and ...... mplications for XSCID and XCID

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Interaction of IL-2R beta and ...... mplications for XSCID and XCID

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B A Witthuhn

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C M Bacon

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D W McVicar

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J A Johnston

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M Berg

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M Friedmann

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M Kawamura

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M Noguchi

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O Silvennoinen

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S M Russell

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10.1126/SCIENCE.7973658

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7973658

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