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A new mechanism of allostery in a G protein-coupled receptor dimer

A new mechanism of allostery in a G protein-coupled receptor dimer

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Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.The First Negative Allosteric Modulator for Dopamine D2 and D3 Receptors, SB269652 May Lead to a New Generation of Antipsychotic Drugs The GPCR heterotetramer: challenging classical pharmacology.Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor.What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?Novobiocin and peptide analogs of α-factor are positive allosteric modulators of the yeast G protein-coupled receptor Ste2p.Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis Computational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled Receptors Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor.Computational approaches to detect allosteric pathways in transmembrane molecular machines.Allosteric proteins as logarithmic sensors Revealing G-protein-coupled receptor oligomerization at the single-molecule level through a nanoscopic lens: methods, dynamics and biological function.Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology.Allosteric Modulators of the Class A G Protein Coupled Receptors.Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders.Pharmacological properties of acid N-thiazolylamide FFA2 agonists.LASSBio-897 Reduces Lung Injury Induced by Silica Particles in Mice: Potential Interaction with the A2A Receptor.The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions.The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R).The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor.Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors.Dopamine D2 receptors dimers: how can we pharmacologically target them?Dual-color reporter switching system to discern dimer formations of G-protein-coupled receptors using Cre/loxP site-specific recombination in yeast.In Vitro and In Vivo Identification of Novel Positive Allosteric Modulators of the Human Dopamine D2 and D3 Receptor.Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology.Current Concepts and Treatments of Schizophrenia

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P2860

A new mechanism of allostery in a G protein-coupled receptor dimer

http://www.wikidata.org/entity/Q28245604

description

2014 nî lūn-bûn

@nan

2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

A new mechanism of allostery in a G protein-coupled receptor dimer

@ast

A new mechanism of allostery in a G protein-coupled receptor dimer

@en

A new mechanism of allostery in a G protein-coupled receptor dimer

@nl

type

label

A new mechanism of allostery in a G protein-coupled receptor dimer

@ast

A new mechanism of allostery in a G protein-coupled receptor dimer

@en

A new mechanism of allostery in a G protein-coupled receptor dimer

@nl

prefLabel

A new mechanism of allostery in a G protein-coupled receptor dimer

@ast

A new mechanism of allostery in a G protein-coupled receptor dimer

@en

A new mechanism of allostery in a G protein-coupled receptor dimer

@nl

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Nature Chemical Biology

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A new mechanism of allostery in a G protein-coupled receptor dimer

@en

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Ben Capuano

http://www.w3.org/2001/XMLSchema#string

Christopher J Draper-Joyce

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Laura López

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Mayako Michino

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Prashant Donthamsetti

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Samuel Dentry

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P2860

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors

Dopamine D2 receptors form higher order oligomers at physiological expression levels

D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum

The tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptors

Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes

Building a new conceptual framework for receptor heteromers

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D(3) receptor antagonist with high oral bioavailability and CNS penetration in t

Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-A

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P304

745-752

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scholarly article

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2486144

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10.1038/NCHEMBIO.1593

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P433

9

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10

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Patrick M. Sexton

Arthur Christopoulos

Jeremy Shonberg

Peter J. Scammells

Jonathan Javitch

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2014-08-10T00:00:00Z

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264631946

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25108820

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G protein-coupled receptor

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4138267

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