A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Purification and characterization of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
about
An empirical extremum principle for the hill coefficient in ligand-protein interactions showing negative cooperativity.Molecular cloning and characterization of murine and human N-acetylglucosamine kinaseThe collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesisMutations in the human UDP-N-acetylglucosamine 2-epimerase gene define the disease sialuria and the allosteric site of the enzymeDiversity of microbial sialic acid metabolismA structural basis for the allosteric regulation of non-hydrolysing UDP-GlcNAc 2-epimerasesMammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifsInsights into muscle degeneration from heritable inclusion body myopathiesGNE is involved in the early development of skeletal and cardiac muscleCrystal Structures of N -Acetylmannosamine Kinase Provide Insights into Enzyme Activity and InhibitionCrystal structures of the archaeal UDP-GlcNAc 2-epimerase from Methanocaldococcus jannaschii reveal a conformational change induced by UDP-GlcNAcPrimary structure and expression analysis of human UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase, the bifunctional enzyme in neuraminic acid biosynthesisHereditary inclusion body myopathy: a decade of progressNon-specific accumulation of glycosphingolipids in GNE myopathyMutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamineDomain-specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinaseTissue expression and amino acid sequence of murine UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinaseAberrant O-GlcNAcylation disrupts GNE enzyme activity in GNE myopathy.Preclinical assessment of wt GNE gene plasmid for management of hereditary inclusion body myopathy 2 (HIBM2)Intravenous immune globulin in hereditary inclusion body myopathy: a pilot studyUDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) binds to alpha-actinin 1: novel pathways in skeletal muscle?Ganglioside GM3 levels are altered in a mouse model of HIBM: GM3 as a cellular marker of the disease.Molecular modeling of the bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase and predictions of structural effects of mutations associated with HIBM and sialuria.Identification of an Alu element-mediated deletion in the promoter region of GNE in siblings with GNE myopathy.Sialylation is essential for early development in mice.Sialylation of Thomsen-Friedenreich antigen is a noninvasive blood-based biomarker for GNE myopathy.UDP-GlcNAc 2-Epimerase/ManNAc Kinase (GNE): A Master Regulator of Sialic Acid Synthesis.Mutation update for GNE gene variants associated with GNE myopathy.Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli.Sialylation and muscle performance: sialic acid is a marker of muscle ageing.Distal myopathy with rimmed vacuoles: impaired O-glycan formation in muscular glycoproteinsIdentification, tissue distribution, and molecular modeling of novel human isoforms of the key enzyme in sialic acid synthesis, UDP-GlcNAc 2-epimerase/ManNAc kinase.The NeuC protein of Escherichia coli K1 is a UDP N-acetylglucosamine 2-epimeraseHereditary inclusion body myopathy: single patient response to intravenous dosing of GNE gene lipoplex.Increased sialylation as a phenomenon in accommodation of the parasitic nematode Trichinella spiralis (Owen, 1835) in skeletal muscle fibres.Sizing up sialic acid in glomerular diseaseThe Gne M712T mouse as a model for human glomerulopathy.Physiologic and pathophysiologic consequences of altered sialylation and glycosylation on ion channel function.Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamineSubstantial deficiency of free sialic acid in muscles of patients with GNE myopathy and in a mouse model
P2860
Q21045434-B93D1438-6CBA-4913-8A8E-9B3CDC4304C3Q22254147-B90DBD45-F59E-4498-BD04-008484AFE623Q24318382-3BD94C74-3892-4359-865D-CD179EE7D3ABQ24540069-AEF52ACC-0815-4AAF-A7DE-4CF8B6B62F56Q24594315-FF16FE60-5DB3-450D-B3FB-AE9EAB38E46DQ24646011-D1511EFE-1496-46FD-B93E-B0558A2582CAQ24684341-96D799C6-9254-4DCF-B4D4-61DFE481C1E7Q26851967-5AF16B51-98C1-44C0-8B92-A83DBA52276CQ27334498-31AE4463-4D26-4FFD-8383-1BB854AC9343Q27677332-14EE28F3-1EC3-4518-A63C-1D478FC8B7B2Q27689000-ED447163-3719-4DAB-B9CE-F7CBFCB984AAQ28141095-D94518D3-9DD6-42B9-8932-9C2DBC17C4C3Q28251720-64AE7682-E274-4633-951C-1ACC2239F7F3Q28300410-764A69CE-585C-4A4B-949D-C6C02D42A6FBQ28305085-C5219889-4CFA-40AB-AEBE-77A9F662FD38Q28569398-E65119BC-93DC-4492-B564-57E8DF5EAA61Q28585184-ECF7DDCD-B778-47BB-8C8B-DEE7793D1C95Q30315345-F58AAD31-7831-4D26-8423-A4B57DD7E4DEQ30489819-1C168489-D709-44F5-96DA-774EDD670C8DQ33270749-4513A0AF-4CD4-4B52-A114-892C078688BDQ33344453-D01A3A14-12D0-40AC-A6ED-10ED7198ADE7Q33552330-991CEDD0-13E5-460F-ACB5-9A65A23D1782Q33627531-AC2AD436-CFC2-4794-A486-4600AFF824E2Q33907000-887A5AF6-A347-43CC-9537-E189E540E5DFQ34024283-83077A66-F7FB-436B-BAAF-E222CEB4E223Q34160071-F7551124-4435-434A-8D68-A76586F98B21Q34167791-50C2A220-B08B-4257-B77B-A4558069E4B4Q34231117-3E7D5261-E9B8-470E-86B9-617AA21B752FQ34484852-1DB1FEF0-0EDD-49C9-B8FD-07F52C58DD6FQ35069379-226819FE-7AE0-4120-9CDA-1A9559CF7B56Q35083807-28100CA9-D410-4B75-B5B6-C0896B15899EQ35336353-6481C93F-2DF4-4E78-ACB4-7FD71C420147Q35545982-4D6AAA32-4303-4345-AB97-92F08957BF9DQ35575697-6BCEBC96-4021-4FD2-B1A6-CDC63732CF17Q35776470-0D08DBED-E1D7-46C6-B838-FF2550128161Q35813769-900A589E-450B-4CD8-A45B-F6F3E3A5EAD7Q35952076-69EC4C9C-14D9-47C3-B72A-B2B4E95EF66EQ35981911-1B44E9F7-D899-4AF0-BCD3-A508CA6E5ADEQ36217214-3C7FD4C4-D84A-4ECB-A4DE-E2455F22E2A5Q36299423-13AD0D7D-654E-448D-B989-A6A5CE6504FA
P2860
A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Purification and characterization of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
description
1997 nî lūn-bûn
@nan
1997 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
A bifunctional enzyme catalyze ...... ase/N-acetylmannosamine kinase
@ast
A bifunctional enzyme catalyze ...... ase/N-acetylmannosamine kinase
@en
A bifunctional enzyme catalyze ...... ase/N-acetylmannosamine kinase
@nl
type
label
A bifunctional enzyme catalyze ...... ase/N-acetylmannosamine kinase
@ast
A bifunctional enzyme catalyze ...... ase/N-acetylmannosamine kinase
@en
A bifunctional enzyme catalyze ...... ase/N-acetylmannosamine kinase
@nl
prefLabel
A bifunctional enzyme catalyze ...... ase/N-acetylmannosamine kinase
@ast
A bifunctional enzyme catalyze ...... ase/N-acetylmannosamine kinase
@en
A bifunctional enzyme catalyze ...... ase/N-acetylmannosamine kinase
@nl
P2093
P2860
P356
P1476
A bifunctional enzyme catalyze ...... ase/N-acetylmannosamine kinase
@en
P2093
S Hinderlich
P2860
P304
P356
10.1074/JBC.272.39.24313
P407
P577
1997-09-26T00:00:00Z