LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway
about
Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesisCombined deficiency of coagulation factors V and VIII: an updateCrystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIIIStructural basis for the cooperative interplay between the two causative gene products of combined factor V and factor VIII deficiencyStructural Characterization of Carbohydrate Binding by LMAN1 Protein Provides New Insight into the Endoplasmic Reticulum Export of Factors V (FV) and VIII (FVIII)Structure of human peptidyl-prolylcis-transisomerase FKBP22 containing two EF-hand motifsStructural Basis for Disparate Sugar-Binding Specificities in the Homologous Cargo Receptors ERGIC-53 and VIP36Chemical chaperones improve protein secretion and rescue mutant factor VIII in mice with hemophilia AMice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsinSEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion.Molecular basis of sugar recognition by the human L-type lectins ERGIC-53, VIPL, and VIP36.Identification of ERGIC-53 as an intracellular transport receptor of alpha1-antitrypsin.EF-hand domains of MCFD2 mediate interactions with both LMAN1 and coagulation factor V or VIII.Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calciumMolecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIIIIn vivo function of the ER-Golgi transport protein LMAN1 in photoreceptor homeostasis.Bioengineering of coagulation factor VIII for efficient expression through elimination of a dispensable disulfide loopA sequence variation scan of the coagulation factor VIII (FVIII) structural gene and associations with plasma FVIII activity levels.Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis.The COPII pathway and hematologic diseaseTransgene-host cell interactions mediate significant influences on the production, stability, and function of recombinant canine FVIIIThe complex interactions of Chs5p, the ChAPs, and the cargo Chs3p.Protein quality control in the early secretory pathwayRare bleeding disorders.A synonymous mutation in LMAN1 creates an ectopic splice donor site and causes combined deficiency of FV and FVIIIGenotype-phenotype correlation in combined deficiency of factor V and factor VIII.Antioxidants reduce endoplasmic reticulum stress and improve protein secretion.Patterns of expression of factor VIII and von Willebrand factor by endothelial cell subsets in vivo.RNA in blood is altered prior to hemorrhagic transformation in ischemic strokeRecent developments in the understanding of the combined deficiency of FV and FVIII.Glycoprotein folding and quality-control mechanisms in protein-folding diseasesMissense mutations near the N-glycosylation site of the A2 domain lead to various intracellular trafficking defects in coagulation factor VIII.Cargo loading at the ER.Inherited hematological disorders due to defects in coat protein (COP)II complex.Blood Clotting Factor VIII: From Evolution to Therapy.Insights into animal and plant lectins with antimicrobial activities.Emerging structural insights into glycoprotein quality control coupled with N-glycan processing in the endoplasmic reticulum.Industrial production of clotting factors: Challenges of expression, and choice of host cells.LMAN1 (ERGIC-53) is a potential carrier protein for matrix metalloproteinase-9 glycoprotein secretion.
P2860
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P2860
LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway
description
2005 nî lūn-bûn
@nan
2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
name
LMAN1 and MCFD2 form a cargo r ...... in the early secretory pathway
@ast
LMAN1 and MCFD2 form a cargo r ...... in the early secretory pathway
@en
LMAN1 and MCFD2 form a cargo r ...... in the early secretory pathway
@nl
type
label
LMAN1 and MCFD2 form a cargo r ...... in the early secretory pathway
@ast
LMAN1 and MCFD2 form a cargo r ...... in the early secretory pathway
@en
LMAN1 and MCFD2 form a cargo r ...... in the early secretory pathway
@nl
prefLabel
LMAN1 and MCFD2 form a cargo r ...... in the early secretory pathway
@ast
LMAN1 and MCFD2 form a cargo r ...... in the early secretory pathway
@en
LMAN1 and MCFD2 form a cargo r ...... in the early secretory pathway
@nl
P2093
P356
P1476
LMAN1 and MCFD2 form a cargo r ...... in the early secretory pathway
@en
P2093
David Ginsburg
Randal J Kaufman
P304
P356
10.1074/JBC.M502160200
P407
P577
2005-07-08T00:00:00Z