DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy - Wikidata - awgldk - TriplyDB

DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy

DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy

http://www.wikidata.org/entity/Q28251037

about

SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway Cullin-RING ligases in regulation of autophagy The role of cullin 5-containing ubiquitin ligases mTOR-dependent cell survival mechanisms Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis.Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis Loss of hepatic DEPTOR alters the metabolic transition to fasting MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1.Circadian gene variants in cancer.The evolution of the TOR pathway and its role in cancer.Nutrient signaling to mTOR and cell growth.Stabilization and Degradation Mechanisms of Cytoplasmic Ataxin-1.Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy The mTOR signaling pathway as a treatment target for intracranial neoplasms β-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells.Ubiquitin carboxyl terminal hydrolyase L1-suppressed autophagic degradation of p21WAF1/Cip1 as a novel feedback mechanism in the control of cardiac fibroblast proliferation The neddylation-cullin 2-RBX1 E3 ligase axis targets tumor suppressor RhoB for degradation in liver cancer.The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR.Deptor enhances triple-negative breast cancer metastasis and chemoresistance through coupling to survivin expression Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy.Rapid mitogenic regulation of the mTORC1 inhibitor, DEPTOR, by phosphatidic acid.Linking metabolism and cell cycle progression via the APC/CCdh1 and SCFβTrCP ubiquitin ligases Deconvoluting mTOR biology Rapamycin inhibits lymphatic endothelial cell tube formation by downregulating vascular endothelial growth factor receptor 3 protein expression.Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 Ligase.Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic application An evolving role for DEPTOR in tumor development and progression.S6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation DEPTOR ubiquitination and destruction by SCF(β-TrCP).Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight.Genes regulated in metastatic osteosarcoma: evaluation by microarray analysis in four human and two mouse cell line systems.mTOR: on target for novel therapeutic strategies in the nervous system.Regulator of cullins-1 expression knockdown suppresses the malignant progression of muscle-invasive transitional cell carcinoma by regulating mTOR/DEPTOR pathway.Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells.Small molecule therapeutics targeting F-box proteins in cancer.Transforming growth factor β integrates Smad 3 to mechanistic target of rapamycin complexes to arrest deptor abundance for glomerular mesangial cell hypertrophy.mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy.Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase DEPTOR suppresses the progression of esophageal squamous cell carcinoma and predicts poor prognosis.

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DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy

http://www.wikidata.org/entity/Q28251037

description

2011 nî lūn-bûn

@nan

2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

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2011年論文

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2011年论文

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name

DEPTOR, an mTOR inhibitor, is ...... gulates survival and autophagy

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DEPTOR, an mTOR inhibitor, is ...... gulates survival and autophagy

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DEPTOR, an mTOR inhibitor, is ...... gulates survival and autophagy

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DEPTOR, an mTOR inhibitor, is ...... gulates survival and autophagy

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DEPTOR, an mTOR inhibitor, is ...... gulates survival and autophagy

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J.MOLCEL.2011.08.029

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DEPTOR, an mTOR inhibitor, is ...... gulates survival and autophagy

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Xiufang Xiong

http://www.w3.org/2001/XMLSchema#string

Yi Sun

http://www.w3.org/2001/XMLSchema#string

Yongchao Zhao

http://www.w3.org/2001/XMLSchema#string

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Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

Systematic analysis and nomenclature of mammalian F-box proteins

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

RING domain E3 ubiquitin ligases

Autophagy in the Pathogenesis of Disease

TSC2 mediates cellular energy response to control cell growth and survival

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22017876

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