Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction
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Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implicationsGenetic insights into the mechanisms of Fgf signalingRoles of FGF Signals in Heart Development, Health, and DiseaseFibroblast growth factors as tissue repair and regeneration therapeutics.Acquired nintedanib resistance in FGFR1-driven small cell lung cancer: role of endothelin-A receptor-activated ABCB1 expressionConformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.Fibroblast Growth Factor Receptor 2 (FGFR2) Is Required for Meibomian Gland Homeostasis in the Adult MouseFGF2/FGFR1 regulates autophagy in FGFR1-amplified non-small cell lung cancer cells.Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells.Regulation of osteosarcoma cell lung metastasis by the c-Fos/AP-1 target FGFR1.Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCĪ³1.FGFR and PTEN signaling interact during lens development to regulate cell survivalTyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model.Gene-based analysis of the fibroblast growth factor receptor signaling pathway in relation to breast cancer in African American women: the AMBER consortium.FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review).Discovery of Substituted 1H-Pyrazolo[3,4-b]pyridine Derivatives as Potent and Selective FGFR Kinase InhibitorsTargeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor.One reporter for in-cell activity profiling of majority of protein kinase oncogenes.Epithelial splicing regulatory protein 1 and 2 paralogues correlate with splice signatures and favorable outcome in human colorectal cancer.Design, Synthesis and Biological Evaluation of 6-(2,6-Dichloro-3,5-dimethoxyphenyl)-4-substituted-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors.Traditional Approaches to Molecular Genetic Analysis.Cell signaling pathways in the adrenal cortex: Links to stem/progenitor biology and neoplasia.Fibroblast growth factor-mediated crosstalk in cancer etiology and treatment.Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use.Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity.Macropinocytic entry of isolated mitochondria in epidermal growth factor-activated human osteosarcoma cells.Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis.Fibroblast Growth Factor Receptor 2 (FGFR2) Mutation Related Syndromic Craniosynostosis.Autocatalytic phosphorylation of FGFR3 fusionsActivated FGFR3 fusions bind FRS2Activated FGFR3 fusions phosphorylate FRS2Activated FGFR3 fusions:p-FRS2 bind GRB2-SOS1FGFR3 fusions:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchangeActivated FGFR3 fusions:p-FRS2 binds GRB2:GAB1:PIK3R1Activated FGFR3 fusions:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CAActivated FGFR3 fusion-associated PI3K phosphorylates PIP2 to PIP3Discovery and Biological Evaluation of a Series of Pyrrolo[2,3-b]pyrazines as Novel FGFR Inhibitors.FGFR-associated craniosynostosis syndromes and gastrointestinal defects.Multikinase activity of fibroblast growth factor receptor (FGFR) inhibitors SU5402, PD173074, AZD1480, AZD4547 and BGJ398 compromises the use of small chemicals targeting FGFR catalytic activity for therapy of short-stature syndromes.PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer.
P2860
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P2860
Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction
description
2015 nĆ® lÅ«n-bĆ»n
@nan
2015 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« Ō±ÕŗÖÕ«Õ¬Õ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕøÖÕ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ ÕµÖ
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@hyw
2015 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« Õ”ÕŗÖÕ«Õ¬Õ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
2015幓ć®č«ę
@ja
2015幓č«ę
@yue
2015幓č«ę
@zh-hant
2015幓č«ę
@zh-hk
2015幓č«ę
@zh-mo
2015幓č«ę
@zh-tw
2015幓č®ŗę
@wuu
name
Careless talk costs lives: fib ...... quences of pathway malfunction
@ast
Careless talk costs lives: fib ...... quences of pathway malfunction
@en
Careless talk costs lives: fib ...... quences of pathway malfunction
@nl
type
label
Careless talk costs lives: fib ...... quences of pathway malfunction
@ast
Careless talk costs lives: fib ...... quences of pathway malfunction
@en
Careless talk costs lives: fib ...... quences of pathway malfunction
@nl
prefLabel
Careless talk costs lives: fib ...... quences of pathway malfunction
@ast
Careless talk costs lives: fib ...... quences of pathway malfunction
@en
Careless talk costs lives: fib ...... quences of pathway malfunction
@nl
P2093
P3181
P1476
Careless talk costs lives: fib ...... quences of pathway malfunction
@en
P2093
Abbie E Fearon
Edward P Carter
Richard P Grose
P304
P3181
P356
10.1016/J.TCB.2014.11.003
P407
P577
2015-04-01T00:00:00Z