about
Intramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthaseKinetic barriers in the isomerization of substituted ureas: implications for computer-aided drug designBiological Stereoselectivity of Atropisomeric Natural Products and DrugsSpontaneous transfer of chirality in an atropisomerically enriched two-axis system.Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L BromodomainsAsymmetric total synthesis of the epoxykinamycin FL-120 B'.Electronically Rich N-Substituted Tetrahydroisoquinoline 3-Carboxylic Acid Esters: Concise Synthesis and Conformational StudiesConcise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: identification of pharmacophoric elements.Atropselective syntheses of (-) and (+) rugulotrosin A utilizing point-to-axial chirality transfer.Regioselective derivatizations of a tribrominated atropisomeric benzamide scaffold.1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119): a cytotoxic prodrug with two stable conformations differing in biological and physical propertiesSynthesis of atropisomerically defined, highly substituted biaryl scaffolds through catalytic enantioselective bromination and regioselective cross-couplingEnantioselective synthesis of atropisomeric benzamides through peptide-catalyzed bromination.Practical Organocatalytic Synthesis of Functionalized Non-C2-Symmetrical Atropisomeric Biaryls.Enantioselective synthesis of 3-arylquinazolin-4(3H)-ones via peptide-catalyzed atroposelective bromination.Synthesis of enantiomerically pure helicene like bis-oxazines from atropisomeric 7,7'-dihydroxy BINOL: Preliminary measurements of the circularly polarized luminescence.Symmetry in Cascade Chirality-Transfer Processes: A Catalytic Atroposelective Direct Arylation Approach to BINOL Derivatives.Macrocylic bisbibenzyl natural products and their chemical synthesis.Axial-to-central chirality transfer in cyclization processes.Organocatalyzed Asymmetric Synthesis of Axially, Planar, and Helical Chiral Compounds.An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol.Measurement of atropisomer racemization kinetics using segmented flow technology.Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation.Templated deprotonative metalation of polyaryl systems: Facile access to simple, previously inaccessible multi-iodoarenes.Enzymatic desymmetrising redox reactions for the asymmetric synthesis of biaryl atropisomers.Dynamic kinetic resolution of biaryl atropisomers via peptide-catalyzed asymmetric bromination.On the nature of C-H···F-C interactions in hindered CF3-C(sp3) bond rotations.Solid Phase Deracemization of an AtropisomerEnantiospecific photochemical transformations under elevated pressure.Vibrational circular dichroism (VCD) chiral assignment of atropisomers: application to γ-aminobutyric acid (GABA) modulators designed as potential anxiolytic drugs.Atropisomeric chiral dienes in asymmetric catalysis: C(2) -symmetric (Z,Z)-2,3-bis[1-(diphenylphosphinyl)ethylidene]tetralin as a highly active Lewis base organocatalyst.Inversion of supramolecular helicity in oligo-p-phenylene-based supramolecular polymers: influence of molecular atropisomerism.Unique structural properties of 2,4,6-tri-tert-butylanilide: isomerization and switching between separable amide rotamers through the reaction of anilide enolates.Exploiting Atropisomerism to Increase the Target Selectivity of Kinase Inhibitors.Phase-transfer-catalyzed asymmetric synthesis of axially chiral anilides.Atropisomerism in medicinal chemistry: challenges and opportunities.Atropisomerism in 3-arylthiazolidine-2-thiones. A combined dynamic NMR and dynamic HPLC study.Reversible crystal-to-crystal chiral resolution: making/breaking non-bonding SO interactions.Catalytic enantioselective synthesis of atropisomeric biaryls by a cation-directed O-alkylation.Stereoselective Arene-Forming Aldol Condensation: Catalyst-Controlled Synthesis of Axially Chiral Compounds.
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009 թուականին հրատարակուած գիտական յօդուած
@hyw
2009 թվականին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The challenge of atropisomerism in drug discovery
@ast
The challenge of atropisomerism in drug discovery
@en
The challenge of atropisomerism in drug discovery
@nl
type
label
The challenge of atropisomerism in drug discovery
@ast
The challenge of atropisomerism in drug discovery
@en
The challenge of atropisomerism in drug discovery
@nl
prefLabel
The challenge of atropisomerism in drug discovery
@ast
The challenge of atropisomerism in drug discovery
@en
The challenge of atropisomerism in drug discovery
@nl
P3181
P356
P1476
The challenge of atropisomerism in drug discovery
@en
P2093
Paul J Edwards
Steven R LaPlante
P304
P3181
P356
10.1002/ANIE.200901719
P407
P577
2009-01-01T00:00:00Z