Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes
about
Altered cardiac electrophysiology and SUDEP in a model of Dravet syndromeChannelopathies from mutations in the cardiac sodium channel protein complexProtein assemblies of sodium and inward rectifier potassium channels control cardiac excitability and arrhythmogenesisXin proteins and intercalated disc maturation, signaling and diseasesRole of the intercalated disc in cardiac propagation and arrhythmogenesisUltrastructure of the intercellular space in adult murine ventricle revealed by quantitative tomographic electron microscopyNanoscale visualization of functional adhesion/excitability nodes at the intercalated disc.TMEM43 mutation p.S358L alters intercalated disc protein expression and reduces conduction velocity in arrhythmogenic right ventricular cardiomyopathyIon channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac deathFibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine heartsCortactin is required for N-cadherin regulation of Kv1.5 channel functionDesmosomes and the sodium channel complex: implications for arrhythmogenic cardiomyopathy and Brugada syndromeInteractions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated discN-cadherin/catenin complex as a master regulator of intercalated disc functionSodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency.Intercalated disc abnormalities, reduced Na(+) current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changesHeterogeneity of ATP-sensitive K+ channels in cardiac myocytes: enrichment at the intercalated diskA novel kind of tumor type-characteristic junction: plakophilin-2 as a major protein of adherens junctions in cardiac myxomataSuper-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaqueCoxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemiaMissense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotypeNew functions for alpha-catenins in health and disease: from cancer to heart regenerationOrdered assembly of the adhesive and electrochemical connections within newly formed intercalated disks in primary cultures of adult rat cardiomyocytesTGF-β1, released by myofibroblasts, differentially regulates transcription and function of sodium and potassium channels in adult rat ventricular myocytesPlakophilin-2 and the migration, differentiation and transformation of cells derived from the epicardium of neonatal rat heartsReduced Na⁺ current density underlies impaired propagation in the diabetic rabbit ventricleSCN5A mutation in Chinese patients with arrhythmogenic right ventricular dysplasia.Phenotypic expression is a prerequisite for malignant arrhythmic events and sudden cardiac death in arrhythmogenic right ventricular cardiomyopathy.Beyond the Electrocardiogram: Mutations in Cardiac Ion Channel Genes Underlie Nonarrhythmic Phenotypes.Microdomain-specific localization of functional ion channels in cardiomyocytes: an emerging concept of local regulation and remodelling.Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart.Voltage-gated sodium channels were differentially expressed in human normal prostate, benign prostatic hyperplasia and prostate cancer cells.Dynamic conduction and repolarisation changes in early arrhythmogenic right ventricular cardiomyopathy versus benign outflow tract ectopy demonstrated by high density mapping & paced surface ECG analysis.Arrhythmogenic cardiomyopathy: diagnosis, genetic background, and risk management.Human iPSC-derived cardiomyocytes cultured in 3D engineered heart tissue show physiological upstroke velocity and sodium current density.Desmosomal molecules in and out of adhering junctions: normal and diseased States of epidermal, cardiac and mesenchymally derived cells.Novel missense mutations in exon 15 of desmoglein-2: role of the intracellular cadherin segment in arrhythmogenic right ventricular cardiomyopathy?Arrhythmogenic right ventricular cardiomyopathy (ARVC): cardiovascular magnetic resonance update.Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivoDiseases caused by mutations in Nav1.5 interacting proteins
P2860
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P2860
Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Loss of plakophilin-2 expressi ...... y in cultured cardiac myocytes
@ast
Loss of plakophilin-2 expressi ...... y in cultured cardiac myocytes
@en
Loss of plakophilin-2 expressi ...... y in cultured cardiac myocytes
@nl
type
label
Loss of plakophilin-2 expressi ...... y in cultured cardiac myocytes
@ast
Loss of plakophilin-2 expressi ...... y in cultured cardiac myocytes
@en
Loss of plakophilin-2 expressi ...... y in cultured cardiac myocytes
@nl
prefLabel
Loss of plakophilin-2 expressi ...... y in cultured cardiac myocytes
@ast
Loss of plakophilin-2 expressi ...... y in cultured cardiac myocytes
@en
Loss of plakophilin-2 expressi ...... y in cultured cardiac myocytes
@nl
P2093
P2860
P1433
P1476
Loss of plakophilin-2 expressi ...... y in cultured cardiac myocytes
@en
P2093
Guadalupe Guerrero-Serna
Gustavo A Patiño
Hassan Musa
Priscila Y Sato
Steven M Taffet
Wanda Coombs
P2860
P304
P356
10.1161/CIRCRESAHA.109.201418
P407
P577
2009-08-06T00:00:00Z