HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
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The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylationThe global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase.Gps2, a protein partner for human papillomavirus E6 proteinsInteraction of zyxin, a focal adhesion protein, with the e6 protein from human papillomavirus type 6 results in its nuclear translocationHuman papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligaseThe E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradationPapillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activationViruses associated with human cancerBinding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor proteinImmortalization of Primary Keratinocytes and Its Application to Skin ResearchGenomic landscape of human papillomavirus-associated cancersHepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotypeFunctional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical SitesHuman papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcriptionChloroform Extract of Rasagenthi Mezhugu, a Siddha Formulation, as an Evidence-Based Complementary and Alternative Medicine for HPV-Positive Cervical CancersStressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cellsStructure based identification and characterization of flavonoids that disrupt human papillomavirus-16 E6 functionAccumulation of human papillomavirus type 16 E7 protein bypasses G1 arrest induced by serum deprivation and by the cell cycle inhibitor p21The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity.Papillomavirus E6 oncoproteins.HPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytesInteraction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteinsThe E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth.Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation.Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoterEstablishment of Immortalized Primary Human Foreskin Keratinocytes and Their Application to Toxicity Assessment and Three Dimensional Skin Culture Construction.Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytesViral E6-E7 transcription in the basal layer of organotypic cultures without apparent p21cip1 protein precedes immortalization of human papillomavirus type 16- and 18-transfected human keratinocytesOverexpression of C/EBPbeta represses human papillomavirus type 18 upstream regulatory region activity in HeLa cells by interfering with the binding of TATA-binding protein.Anchorage-independent transcription of the cyclin A gene induced by the E7 oncoprotein of human papillomavirus type 16.Repression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells.Human papillomavirus 16 E5 oncogene contributes to two stages of skin carcinogenesisHuman papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligasep53 Loss synergizes with estrogen and papillomaviral oncogenes to induce cervical and breast cancers.Human papillomavirus type 16 E6-induced degradation of E6TP1 correlates with its ability to immortalize human mammary epithelial cells.Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein.Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes.Fowlpox virus recombinants expressing HPV-16 E6 and E7 oncogenes for the therapy of cervical carcinoma elicit humoral and cell-mediated responses in rabbits.Spontaneous and Vaccine-Induced Clearance of Mus Musculus Papillomavirus 1 Infection
P2860
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P2860
HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
description
1989 nî lūn-bûn
@nan
1989 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
@ast
HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
@en
HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
@nl
type
label
HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
@ast
HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
@en
HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
@nl
prefLabel
HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
@ast
HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
@en
HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
@nl
P2093
P2860
P3181
P1433
P1476
HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
@en
P2093
J T Schiller
K H Vousden
N L Hubbert
P Hawley-Nelson
P2860
P304
P3181
P407
P577
1989-12-01T00:00:00Z