Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function - Wikidata - awgldk - TriplyDB

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

http://www.wikidata.org/entity/Q28254826

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Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation Updates of mTOR inhibitors Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B, the plant homologue of a major regulator of eukaryotic cell growth Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects Saccharomyces cerevisiae FKBP12 binds Arabidopsis thaliana TOR and its expression in plants leads to rapamycin susceptibility.Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site InTERTesting association between telomerase, mTOR and phytochemicals Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes Cell growth control: little eukaryotes make big contributions.Local translation in primary afferent fibers regulates nociception mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action Novel targets for the treatment of autosomal dominant polycystic kidney disease.Rapamycin sensitizes Akt inhibition in malignant human breast epithelial cells.Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophy Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment.The abundance and activation of mTORC1 regulators in skeletal muscle of neonatal pigs are modulated by insulin, amino acids, and age.Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.Sepsis-induced alterations in protein-protein interactions within mTOR complex 1 and the modulating effect of leucine on muscle protein synthesis Longevity, aging and rapamycin.The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes.mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging.Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer.Stoichiometry and assembly of mTOR complexes revealed by single-molecule pulldown.Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids Rapamycin treatment improves neuron viability in an in vitro model of stroke.Role of mTOR downstream effector signaling molecules in Francisella tularensis internalization by murine macrophages.Relieving autophagy and 4EBP1 from rapamycin resistance.Regulation of protein synthesis by amino acids in muscle of neonates.Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders.Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1 Leucine supplementation improves adiponectin and total cholesterol concentrations despite the lack of changes in adiposity or glucose homeostasis in rats previously exposed to a high-fat diet.Increase of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of rapamycin regulated proteins following mithramycin treatment of human erythroid cells.L-DOPA-Induced Dyskinesia and Abnormal Signaling in Striatal Medium Spiny Neurons: Focus on Dopamine D1 Receptor-Mediated Transmission.Intermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs.

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Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

http://www.wikidata.org/entity/Q28254826

description

2004 nî lūn-bûn

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2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2004 թվականի ապրիլին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Dissociation of raptor from mT ...... ed inhibition of mTOR function

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Dissociation of raptor from mT ...... ed inhibition of mTOR function

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Dissociation of raptor from mT ...... ed inhibition of mTOR function

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Dissociation of raptor from mT ...... ed inhibition of mTOR function

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Dissociation of raptor from mT ...... ed inhibition of mTOR function

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Dissociation of raptor from mT ...... ed inhibition of mTOR function

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Dissociation of raptor from mT ...... ed inhibition of mTOR function

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Dissociation of raptor from mT ...... ed inhibition of mTOR function

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Dissociation of raptor from mT ...... ed inhibition of mTOR function

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J.1356-9597.2004.00727.X

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Dissociation of raptor from mT ...... ed inhibition of mTOR function

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Chiharu Tokunaga

http://www.w3.org/2001/XMLSchema#string

Joseph Avruch

http://www.w3.org/2001/XMLSchema#string

Kazuyoshi Yonezawa

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Ken-ichi Yoshino

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Noriko Oshiro

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Satoshi Eguchi

http://www.w3.org/2001/XMLSchema#string

Sujuti Hidayat

http://www.w3.org/2001/XMLSchema#string

P2860

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

TOR, a central controller of cell growth.

Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

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359-66

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10.1111/J.1356-9597.2004.00727.X

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2004-04-01T00:00:00Z

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15066126

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