The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma
about
Shepherding AKT and androgen receptor by Ack1 tyrosine kinaseInhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor proteinTransforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1Fragile histidine triad protein, WW domain-containing oxidoreductase protein Wwox, and activator protein 2gamma expression levels correlate with basal phenotype in breast cancerWWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcomeTumor suppressor and hepatocellular carcinomaA novel approach to simultaneously scan genes at fragile sites17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo.Functional genetic variant of WW domain-containing oxidoreductase (WWOX) gene is associated with hepatocellular carcinoma risk.Wwox-Brca1 interaction: role in DNA repair pathway choiceFhit loss in lung preneoplasia: relation to DNA damage response checkpoint activation.Molecular alterations in the tumor suppressor gene WWOX in oral leukoplakias.WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy.Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor statusAssociation between decreased WWOX protein expression and thyroid cancer developmentWWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.Oncosuppressor proteins of fragile sites are reduced in cervical cancer.Molecular analysis of WWOX expression correlation with proliferation and apoptosis in glioblastoma multiformeDrosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species.Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression.Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss-induced global genome instabilityThe cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct bindingFHIT gene expression is repressed by mitogenic signaling through the PI3K/AKT/FOXO pathway.Response of subtype-specific human breast cancer-derived cells to poly(ADP-ribose) polymerase and checkpoint kinase 1 inhibition.Expression of WW domain-containing oxidoreductase WWOX in pterygiumAberrant crypt focus and fragile histidine triad protein in sporadic colorectal carcinoma.Tumor Suppressor WWOX and p53 Alterations and Drug Resistance in Glioblastomas.WWOX in biological control and tumorigenesis.Aberrant expression of DNA damage response proteins is associated with breast cancer subtype and clinical featuresThe JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX.Roles of the WWOX in pathogenesis and endocrine therapy of breast cancer.Strategies of oncogenic microbes to deal with WW domain-containing oxidoreductaseCoordinate loss of fragile gene expression in pancreatobiliary cancers: correlations among markers and clinical featuresEpigenetic alterations in the breast: Implications for breast cancer detection, prognosis and treatment.Nit1 and Fhit tumor suppressor activities are additive.Fhit loss-associated initiation and progression of neoplasia in vitro.WWOX gene and gene product: tumor suppression through specific protein interactions.WW domain-containing oxidoreductase's role in myriad cancers: clinical significance and future implications.Common Chromosomal Fragile Site Gene WWOX in Metabolic Disorders and TumorsThe common fragile site FRA16D gene product WWOX: roles in tumor suppression and genomic stability.
P2860
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P2860
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma
@ast
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma
@en
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma
@nl
type
label
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma
@ast
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma
@en
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma
@nl
prefLabel
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma
@ast
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma
@en
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma
@nl
P2093
P3181
P356
P1433
P1476
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma
@en
P2093
Aysegul Uner
Dimitrios Iliopoulos
Gulnur Guler
Kay Huebner
Nilufer Guler
Peter McCue
Shuang-Yin Han
Walter W Hauck
P304
P3181
P356
10.1002/CNCR.20137
P407
P577
2004-04-15T00:00:00Z