Lowe syndrome patient fibroblasts display Ocrl1-specific cell migration defects that cannot be rescued by the homologous Inpp5b phosphatase
about
A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1The epsin family of endocytic adaptors promotes fibrosarcoma migration and invasionThe Lowe syndrome protein OCRL1 is involved in primary cilia assemblyOCRL localizes to the primary cilium: a new role for cilia in Lowe syndromeThe PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathwayOCRL1 function in renal epithelial membrane trafficThe cellular and physiological functions of the Lowe syndrome protein OCRL1OCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates.The oculocerebrorenal syndrome of Lowe: an updateSac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.Crystal structure of the Rab binding domain of OCRL1 in complex with Rab8 and functional implications of the OCRL1/Rab8 module for Lowe syndromeImpaired neural development in a zebrafish model for Lowe syndromeTriggering actin comets versus membrane ruffles: distinctive effects of phosphoinositides on actin reorganizationRhoGTPase-binding proteins, the exocyst complex and polarized vesicle traffickingLowe Syndrome protein OCRL1 supports maturation of polarized epithelial cells.Ciliopathies: the trafficking connection.Species-specific difference in expression and splice-site choice in Inpp5b, an inositol polyphosphate 5-phosphatase paralogous to the enzyme deficient in Lowe SyndromeCompensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe.The Lowe syndrome protein OCRL1 is required for endocytosis in the zebrafish pronephric tubule.Fibronectin attachment protein from bacillus Calmette-Guerin as targeting agent for bladder tumor cells.The 5-phosphatase OCRL mediates retrograde transport of the mannose 6-phosphate receptor by regulating a Rac1-cofilin signalling module.OCRL1 modulates cilia length in renal epithelial cells.The 5-phosphatase OCRL in Lowe syndrome and Dent disease 2.OCRL controls trafficking through early endosomes via PtdIns4,5P₂-dependent regulation of endosomal actin.Lowe syndrome: Between primary cilia assembly and Rac1-mediated membrane remodeling.Loss of OCRL increases ciliary PI(4,5)P2 in Lowe oculocerebrorenal syndrome.OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B-independent phenotypic variability relatively to Lowe syndrome cells
P2860
Q24294988-DCFA15FE-A7BA-4ECA-B34D-8AC28173BD6FQ24295295-C6E93F4B-BEBB-4F1E-9725-E94F63AC8BA6Q24301336-49B7EEF0-B94C-4DDF-BA06-753365C9A30FQ24318114-09F58F45-2AF6-4B26-B62B-DC16B94F229AQ24336978-418DC744-DD63-4689-8712-C60C8270DE5AQ24647354-2F84A400-7285-4379-8E8E-50596297395CQ26862286-A7C07F38-E9A8-4219-97F3-0AF1B3FDB4B2Q27305561-FEE6ABBB-F754-43E6-BD3B-AEEDAB4F5636Q28075516-6F889AD8-7163-49C4-BE8D-1B11B93D73C8Q28117913-87C6E479-D0DC-4502-A34F-033B83F0707DQ29543937-C31103F9-7FF7-4516-B11C-64D6ABE26447Q30512197-3FE6DD80-E8E0-4FA1-8181-9D8D3380E711Q30515754-9A6FCCDC-E64A-4AD7-A2C5-A6D065185377Q33967748-FE93D6AD-CBD1-4826-81E9-0982F5043F55Q34013799-166893FC-4BEB-4862-9242-FFFE560C3B8CQ34207085-582E72CE-6234-4743-BC70-B1C20978B5A7Q34280572-14812D8D-7491-406E-8F47-F26376AC6F9FQ34785564-8ED28E8A-F682-4101-B6EB-29B01D2D9203Q35594661-5BF4D450-13E2-42F5-9FFC-891F958A6E0FQ35748491-19BC7319-C686-43DD-BC78-4E54FBFD026CQ36375795-CAA5F71C-3112-4587-83C5-AB68236A1B90Q36838519-989AE631-C658-4F4D-8253-36FBB2DC9198Q39410095-91C70307-11D0-4F53-9F99-9FE56BBB6326Q39463370-6931FCEB-511C-4F5C-BB4B-40497516BA32Q42227983-85B1E6F0-72CA-44F0-8472-1AD8634E9517Q47629569-201D45DC-B239-4140-BF79-B40206894764Q58117464-4718849E-01A0-49C2-9DED-92B466792C43
P2860
Lowe syndrome patient fibroblasts display Ocrl1-specific cell migration defects that cannot be rescued by the homologous Inpp5b phosphatase
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Lowe syndrome patient fibrobla ...... homologous Inpp5b phosphatase
@ast
Lowe syndrome patient fibrobla ...... homologous Inpp5b phosphatase
@en
Lowe syndrome patient fibrobla ...... homologous Inpp5b phosphatase
@nl
type
label
Lowe syndrome patient fibrobla ...... homologous Inpp5b phosphatase
@ast
Lowe syndrome patient fibrobla ...... homologous Inpp5b phosphatase
@en
Lowe syndrome patient fibrobla ...... homologous Inpp5b phosphatase
@nl
prefLabel
Lowe syndrome patient fibrobla ...... homologous Inpp5b phosphatase
@ast
Lowe syndrome patient fibrobla ...... homologous Inpp5b phosphatase
@en
Lowe syndrome patient fibrobla ...... homologous Inpp5b phosphatase
@nl
P2093
P3181
P356
P1476
Lowe syndrome patient fibrobla ...... homologous Inpp5b phosphatase
@en
P2093
Brian G Coon
Claudia B Hanna
Debarati Mukherjee
Martin Lowe
R Claudio Aguilar
P304
P3181
P356
10.1093/HMG/DDP407
P407
P577
2009-08-21T00:00:00Z