Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors - Wikidata - awgldk - TriplyDB

Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors

Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors

http://www.wikidata.org/entity/Q28256910

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Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome Introducing intermediate filaments: from discovery to disease Molecular insights into the premature aging disease progeria The nuclear envelope: an intriguing focal point for neurogenetic disease Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies Prelamin A farnesylation and progeroid syndromes Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging Sequence dependence and differential expression of Ggamma5 subunit isoforms of the heterotrimeric G proteins variably processed after prenylation in mammalian cells.Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A.The posttranslational processing of prelamin A and disease.Discordant gene expression signatures and related phenotypic differences in lamin A- and A/C-related Hutchinson-Gilford progeria syndrome (HGPS).Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice.Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation.Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome.DNA-damage accumulation and replicative arrest in Hutchinson-Gilford progeria syndrome Nuclear lamins."Laminopathies": a wide spectrum of human diseases.Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging.Chromatin remodeling, DNA damage repair and aging.DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome.Protein isoprenylation regulates osteogenic differentiation of mesenchymal stem cells: effect of alendronate, and farnesyl and geranylgeranyl transferase inhibitors.Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin Nuclear lamins and chromatin: when structure meets function.Nuclear lamins: key regulators of nuclear structure and activities HIV protease inhibitors and nuclear lamin processing: getting the right bells and whistles.Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteins Targeting Mitogen-Activated Protein Kinase Signaling in Mouse Models of Cardiomyopathy Caused by Lamin A/C Gene Mutations Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches.Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin A proteomic approach to identify candidate substrates of human adenovirus E4orf6-E1B55K and other viral cullin-based E3 ubiquitin ligases.Sizing up the nucleus: nuclear shape, size and nuclear-envelope assembly.ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders.Prelamin A Accumulation Attenuates Rac1 Activity and Increases the Intrinsic Migrational Persistence of Aged Vascular Smooth Muscle Cells.Progeria Research Day at Brunel University.Lamina-associated polypeptide (LAP)2α and nucleoplasmic lamins in adult stem cell regulation and disease.Lamins at the crossroads of mechanosignaling Hutchinson-Gilford progeria syndrome as a model for vascular aging.Lamins in the nuclear interior - life outside the lamina.Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling.

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P2860

Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors

http://www.wikidata.org/entity/Q28256910

description

2006 nî lūn-bûn

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2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2006 թվականի հուլիսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors

@ast

Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors

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Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors

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type

label

Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors

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Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors

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Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors

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prefLabel

Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors

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Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors

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Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors

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Journal of Cell Science

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Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors

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P2093

A. E. Rusinol

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Antonio E Rusiñol

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Michael S Sinensky

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3265-3272

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scholarly article

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10.1242/JCS.03156

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16

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Pt 16

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119

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2006-07-25T00:00:00Z

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2006-08-15T00:00:00Z

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6887067

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16899817

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