about
Bioimage informatics: a new area of engineering biology.Fluorescent protein biosensors applied to microphysiological systemsTarget identification by image analysisVisualizing chemical structure-subcellular localization relationships using fluorescent small molecules as probes of cellular transportNew concepts for building vocabulary for cell image ontologiesMicroengineering methods for cell-based microarrays and high-throughput drug-screening applicationsData integration: challenges for drug discovery.Identification of a small molecule that induces mitotic arrest using a simplified high-content screening assay and data analysis method.Quantitative cell-based high-content screening for vasopressin receptor agonists using transfluor technology.Analysis of cellular events using CellCard System in cell-based high-content multiplexed assays.High-content imaging analysis of the knockdown effects of validated siRNAs and antisense oligonucleotides.Machine vision-assisted analysis of structure-localization relationships in a combinatorial library of prospective bioimaging probes.Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling.A personal perspective on high-content screening (HCS): from the beginning.A quantitative, facile, and high-throughput image-based cell migration method is a robust alternative to the scratch assay.A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.A high-content screening assay in transgenic zebrafish identifies two novel activators of fgf signaling1Click1View: interactive visualization methodology for RNAi cell-based microscopic screening.Drug target inference through pathway analysis of genomics data.Prospecting for Live Cell BioImaging Probes With Cheminformatic Assisted Image Arrays (CAIA)Functional interrogation of breast cancer: from models to drugs.Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myelomaQuantification of nanoparticles at the single-cell level: an overview about state-of-the-art techniques and their limitations.Genetic and proteomic approaches to identify cancer drug targets.Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening.Can cell systems biology rescue drug discovery?Correlating intracellular nonviral polyplex localization with transfection efficiency using high-content screeningA Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine.Cell migration and invasion assays as tools for drug discovery.A metric and workflow for quality control in the analysis of heterogeneity in phenotypic profiles and screensThe future of microfluidic assays in drug development.High-content analysis in toxicology: screening substances for human toxicity potential, elucidating subcellular mechanisms and in vivo use as translational safety biomarkers.Detecting and overcoming systematic bias in high-throughput screening technologies: a comprehensive review of practical issues and methodological solutions.High-content screening technology for studying drug-induced hepatotoxicity in cell models.Drug-target interaction prediction: databases, web servers and computational models.The development of high-content screening (HCS) technology and its importance to drug discovery.Alisol F 24 Acetate Enhances Chemosensitivity and Apoptosis of MCF-7/DOX Cells by Inhibiting P-Glycoprotein-Mediated Drug Efflux.Development of an image-based screening system for inhibitors of the plastidial MEP pathway and of protein geranylgeranylation.Salvianolic acid A attenuates TNF-α- and D-GalN-induced ER stress-mediated and mitochondrial-dependent apoptosis by modulating Bax/Bcl-2 ratio and calcium release in hepatocyte LO2 cells.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Advances in high content screening for drug discovery
@ast
Advances in high content screening for drug discovery
@en
Advances in high content screening for drug discovery
@nl
type
label
Advances in high content screening for drug discovery
@ast
Advances in high content screening for drug discovery
@en
Advances in high content screening for drug discovery
@nl
prefLabel
Advances in high content screening for drug discovery
@ast
Advances in high content screening for drug discovery
@en
Advances in high content screening for drug discovery
@nl
P2093
P1476
Advances in high content screening for drug discovery
@en
P2093
D Lansing Taylor
Jeffrey R Haskins
Kenneth A Giuliano
P304
P356
10.1089/154065803322302826
P407
P577
2003-08-01T00:00:00Z