Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease - Wikidata - awgldk - TriplyDB

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

http://www.wikidata.org/entity/Q28257086

about

Parkinson's disease: from monogenic forms to genetic susceptibility factors Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2 PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons Mutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson disease Exclusion of PINK1 as candidate gene for the late-onset form of Parkinson's disease in two European populations.Mitochondrial dysfunction in Parkinson's disease Regulation of Cell Death by IAPs and Their Antagonists The yeast HtrA orthologue Ynm3 is a protease with chaperone activity that aids survival under heat stress.Mitochondrial protein quality control: the mechanisms guarding mitochondrial health Identification of TMEM230 mutations in familial Parkinson's disease The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway The mitochondrial serine protease HtrA2/Omi: an overview Cell biology. Metabolic control of cell death Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1 Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin Parkinson's Disease and Cognitive Impairment Regulation of parkin and PINK1 by neddylation.Genetic susceptibility in Parkinson's disease Lack of replication of association between GIGYF2 variants and Parkinson disease.Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls.Hyperexcitable substantia nigra dopamine neurons in PINK1- and HtrA2/Omi-deficient mice.Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease.Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders.Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins.Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's disease Candidate genes for chromosomes 6 and 10 quantitative trait loci for age-related retinal degeneration in mice.Dynamic changes of the phosphoproteome in postmortem mouse brains.The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity Unravelling the role of defective genes.Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.Resolving candidate genes of mouse skeletal muscle QTL via RNA-Seq and expression network analyses The genetic background of Parkinson's disease: current progress and future prospects.The genetics of Parkinson disease.Mitochondrial morphogenesis, distribution, and Parkinson disease: insights from PINK1

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P2860

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

http://www.wikidata.org/entity/Q28257086

description

2005 nî lūn-bûn

@nan

2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2005年の論文

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2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

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name

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

@ast

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

@en

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

@nl

type

label

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

@ast

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

@en

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

@nl

prefLabel

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

@ast

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

@en

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

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P1433

Human Molecular Genetics

P1476

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

@en

P2093

Antje Bornemann

http://www.w3.org/2001/XMLSchema#string

Frank P Marx

http://www.w3.org/2001/XMLSchema#string

Karsten M Strauss

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L Miguel Martins

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Sabine Kautzmann

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Thomas Müller

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Zbginiew Wszolek

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2099-111

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scholarly article

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5582

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10.1093/HMG/DDI215

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15

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14

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Helene Plun-Favreau

Hartwig Wolburg

Julian Downward

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2005-08-01T00:00:00Z

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15961413

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P921

Parkinson's disease