Structure-based drug design and the discovery of aliskiren (Tekturna): perseverance and creativity to overcome a R&D; pipeline challenge

Structure-based drug design and the discovery of aliskiren (Tekturna): perseverance and creativity to overcome a R&D; pipeline challenge

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http://www.wikidata.org/entity/Q28257168
Trypanosoma cruzi trans-Sialidase in Complex with a Neutralizing Antibody: Structure/Function Studies towards the Rational Design of InhibitorsFrom laptop to benchtop to bedside: structure-based drug design on protein targets.Development, evaluation and application of 3D QSAR Pharmacophore model in the discovery of potential human renin inhibitors.Thermodynamic Proxies to Compensate for Biases in Drug Discovery Methods.Identification of small molecule inhibitors for influenza a virus using in silico and in vitro approaches.Multi-step usage of in vivo models during rational drug design and discovery.Synthesis of amino heterocycle aspartyl protease inhibitors.High-throughput screening and structure-based approaches to hit discovery: is there a clear winner?Aliskiren improves insulin resistance and ameliorates diabetic vascular complications in db/db mice.Aliskiren protecting atrial structural remodeling from rapid atrial pacing in a canine model.The development of the direct renin inhibitor aliskiren: treating hypertension and beyond
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Structure-based drug design and the discovery of aliskiren (Tekturna): perseverance and creativity to overcome a R&D; pipeline challenge

Item
http://www.wikidata.org/entity/Q28257168
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年论文
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Structure-based drug design an ...... come a R&D; pipeline challenge
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Structure-based drug design an ...... come a R&D; pipeline challenge
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10.1111/J.1747-0285.2007.00599.X
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