LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor - Wikidata - awgldk - TriplyDB

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

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Open access chemical probes for epigenetic targets NMR Fragment Screening Hit Induces Plasticity of BRD7/9 Bromodomains Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network.Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain.Design of chiral urea-quaternary ammonium salt hybrid catalysts for asymmetric reactions of glycine Schiff bases Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.Selective targeting of Bromodomains of the Bromodomain-PHD Fingers family impairs osteoclast differentiation.Progress in the Development of non-BET Bromodomain Chemical Probes.Targeting epigenetic regulators for cancer therapy: modulation of bromodomain proteins, methyltransferases, demethylases, and microRNAs.Epigenomic regulation of oncogenesis by chromatin remodeling.Selective targeting of epigenetic reader domains.Bromodomains in Protozoan Parasites: Evolution, Function, and Opportunities for Drug Development.Biological function and histone recognition of family IV bromodomain-containing proteins.Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology.Structural features and inhibitors of bromodomains.Towards the total synthesis of keramaphidin B.Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.Chemical probes and inhibitors of bromodomains outside the BET family.Highlights from SelectBio 2015: Academic Drug Discovery Conference, Cambridge, UK, 19-20 May 2015.Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.A New Way Forward in Cancer Drug Discovery: Inhibiting the SWI/SNF Chromatin Remodelling Complex.Identifying Small-Molecule Binding Sites for Epigenetic Proteins at Domain-Domain Interfaces.Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple).Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03115j.Gold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones

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LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

http://www.wikidata.org/entity/Q28260305

description

2015 nî lūn-bûn

@nan

2015 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի մայիսին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

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LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

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LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

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LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

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LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

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LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

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LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

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LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

@en

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

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Angewandte Chemie International Edition

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LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

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Catherine M Rogers

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Cynthia Tallant

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Danette L Daniels

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Darren J Dixon

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Dean C Singleton

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Jacqui Méndez

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James M Bennett

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Lucas C C Vieira

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Octovia P Monteiro

http://www.w3.org/2001/XMLSchema#string

Oleg Fedorov

http://www.w3.org/2001/XMLSchema#string

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6217-21

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scholarly article

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2056355

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10.1002/ANIE.201501394

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21

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54

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Susanne Müller

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2015-05-18T00:00:00Z

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274902089

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25864491

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