Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy - Wikidata - awgldk - TriplyDB

Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy

Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy

http://www.wikidata.org/entity/Q28260415

about

BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy Targeting the apoptosis pathway in hematologic malignancies A designed redox-controlled caspase Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation Tailoring small molecules for an allosteric site on procaspase-6 PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3 Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs Discovery and canine preclinical assessment of a nontoxic procaspase-3-activating compound Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics The Concise Guide to PHARMACOLOGY 2013/14: enzymes.Local caspase activation interacts with Slit-Robo signaling to restrict axonal arborization.ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1).Small-molecule activators of a proenzyme.Synthesis of a high-purity chemical library reveals a potent inducer of oxidative stress Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.Allosteric regulation of protease activity by small molecules.The potential for caspases in drug discovery Novel proapoptotic agent SM-1 enhances the inhibitory effect of 5-fluorouracil on colorectal cancer cells in vitro and in vivo Differential requirements of Hsp90 and DNA for the formation of estrogen receptor homodimers and heterodimers.Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain A bifunctional allosteric site in the dimer interface of procaspase-3 Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1)Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis Schiff bases of indoline-2,3-dione (isatin) with potential antiproliferative activity.Caspase functions in cell death and disease.Expression of executioner procaspases and their activation by a procaspase-activating compound in chronic lymphocytic leukemia cells Molecular mechanisms of leptin and pro-apoptotic signals induced by menadione in HepG2 cells.Small-molecule procaspase activators identified using fluorescence polarization.Effector caspases and leukemia Targeting cell death in tumors by activating caspases.Turning on caspases with genetics and small molecules The BH4 domain of anti-apoptotic Bcl-XL, but not that of the related Bcl-2, limits the voltage-dependent anion channel 1 (VDAC1)-mediated transfer of pro-apoptotic Ca2+ signals to mitochondria.A novel caspase 8 selective small molecule potentiates TRAIL-induced cell death.Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.Derivatives of Procaspase-Activating Compound 1 (PAC-1) and their Anticancer Activities.Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer.

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Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy

http://www.wikidata.org/entity/Q28260415

description

2006 nî lūn-bûn

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2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2006 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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Nature Chemical Biology

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Small-molecule activation of p ...... rsonalized anticancer strategy

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Daniel R Doerge

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Grace W Chen

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Hua Jin

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Jennifer M Pearson

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Joseph S Sandhorst

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Jung-Taek Kwon

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Karson S Putt

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Martin S Hoagland

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Mona I Churchwell

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Myung-Haing Cho

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P2860

Characterization of the interleukin-1beta-converting enzyme/ced-3-family protease, caspase-3/CPP32, in Hodgkin's disease: lack of caspase-3 expression in nodular lymphocyte predominance Hodgkin's disease.

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543-50

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4410043

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10.1038/NCHEMBIO814

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10

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2

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2006-10-01T00:00:00Z

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1016856142

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16936720

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