Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders
about
Pharmacological targeting of the serotonergic system for the treatment of obesityObesity pharmacotherapy: current perspectives and future directionsThe serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's diseaseStudy of a mechanism responsible for potential antidepressant activity of EMD 386088, a 5-HT6 partial agonist in ratsNew central targets for the treatment of obesity.Pharmacological management of binge eating disorder: current and emerging treatment options.Fluoxetine prevents 8-OH-DPAT-induced hyperphagia in Fischer inbred ratsAlzheimer's disease and age-related memory decline (preclinical)Current and future drug targets in weight managementThe utility of animal models to evaluate novel anti-obesity agents.Combination of Pharmacophore Matching, 2D Similarity Search, and In Vitro Biological Assays in the Selection of Potential 5-HT6 Antagonists from Large Commercial Repositories.Dynamic 5-HT2C receptor editing in a mouse model of obesity.Neuronal ciliary signaling in homeostasis and disease.Idalopirdine - a small molecule antagonist of 5-HT6 with therapeutic potential against obesity.5-HT(6) receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms.Increased expression of the 5-HT6 receptor by viral mediated gene transfer into posterior but not anterior dorsomedial striatum interferes with acquisition of a discrete action-outcome task.Serotonin and the regulation of mammalian energy balance.The medicinal chemistry of 5-HT6 receptor ligands with a focus on arylsulfonyltryptamine analogs.5-hydroxytryptamine subtype 6 receptor modulators: a patent survey.Serotonin and molecular neuroimaging in humans using PET.Atypical antipsychotic-induced weight gain: insights into mechanisms of action.The serotonin-6 receptor as a novel therapeutic target.5HT(6) receptor antagonists: a patent update. Part 1. Sulfonyl derivatives.Novel thiazole derivatives: a patent review (2008 - 2012. Part 2).Antidepressant-like activity of EMD 386088, a 5-HT6 receptor partial agonist, following systemic acute and chronic administration to rats.5-hydroxytryptamine medications for the treatment of obesity.Investigational drugs targeting 5-HT6 receptors for the treatment of Alzheimer's disease.Modulating 5-HT4 and 5-HT6 receptors in Alzheimer's disease treatment.AVN-492, A Novel Highly Selective 5-HT6R Antagonist: Preclinical Evaluation.Approved and Off-Label Uses of Obesity Medications, and Potential New Pharmacologic Treatment Options.Distribution of cells responsive to 5-HT₆ receptor antagonist-induced hypophagia.Serotonin 5-HT6 Receptor Antagonists in Alzheimer's Disease: Therapeutic Rationale and Current Development Status.Novel and Potent 5-Piperazinyl Methyl-N 1-aryl Sulfonyl Indole Derivatives as 5-HT6 Receptor LigandsSerotonergic Control of Metabolic Homeostasis.The 5-HT₂C receptor agonist, lorcaserin, and the 5-HT₆ receptor antagonist, SB-742457, promote satiety; a microstructural analysis of feeding behaviour.Metabolic and Cardiovascular Benefits and Risks of EMD386088-A 5-HT6 Receptor Partial Agonist and Dopamine Transporter Inhibitor.The 5-HT6 receptor agonist EMD 386088 produces antidepressant and anxiolytic effects in rats after intrahippocampal administration.Selective serotonin receptor stimulation of the medial nucleus accumbens differentially affects appetitive motivation for food on a progressive ratio schedule of reinforcement.The 5-hydroxytryptamine (serotonin) receptor 6 agonist EMD 386088 ameliorates ketamine-induced deficits in attentional set shifting and novel object recognition, but not in the prepulse inhibition in rats.Idalopirdine, a selective 5-HT6 receptor antagonist, reduces food intake and body weight in a model of excessive eating.
P2860
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P2860
Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Selective 5-HT6 receptor ligan ...... nd related metabolic disorders
@ast
Selective 5-HT6 receptor ligan ...... nd related metabolic disorders
@en
Selective 5-HT6 receptor ligan ...... nd related metabolic disorders
@nl
type
label
Selective 5-HT6 receptor ligan ...... nd related metabolic disorders
@ast
Selective 5-HT6 receptor ligan ...... nd related metabolic disorders
@en
Selective 5-HT6 receptor ligan ...... nd related metabolic disorders
@nl
prefLabel
Selective 5-HT6 receptor ligan ...... nd related metabolic disorders
@ast
Selective 5-HT6 receptor ligan ...... nd related metabolic disorders
@en
Selective 5-HT6 receptor ligan ...... nd related metabolic disorders
@nl
P2093
P3181
P1476
Selective 5-HT6 receptor ligan ...... nd related metabolic disorders
@en
P2093
P304
P3181
P356
10.1016/J.PHARMTHERA.2007.08.006
P407
P577
2008-02-01T00:00:00Z