Isoform diversity, regulation, and functional adaptation of troponin and calponin
about
Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused reviewProtein Structure-Function Relationship at Work: Learning from Myopathy Mutations of the Slow Skeletal Muscle Isoform of Troponin TPhosphorylation, but not alternative splicing or proteolytic degradation, is conserved in human and mouse cardiac troponin TCalcium-regulated conformational change in the C-terminal end segment of troponin I and its binding to tropomyosinMyofilament incorporation determines the stoichiometry of troponin I in transgenic expression and the rescue of a null mutationThe heart-specific NH2-terminal extension regulates the molecular conformation and function of cardiac troponin IDeletion of a genomic segment containing the cardiac troponin I gene knocks down expression of the slow troponin T gene and impairs fatigue tolerance of diaphragm muscleToad heart utilizes exclusively slow skeletal muscle troponin T: an evolutionary adaptation with potential functional benefitsExpression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscleRestricted N-terminal truncation of cardiac troponin T: a novel mechanism for functional adaptation to energetic crisisLocalization of the two tropomyosin-binding sites of troponin TAdaptation by alternative RNA splicing of slow troponin T isoforms in type 1 but not type 2 Charcot-Marie-Tooth diseaseTroponin T isoforms and posttranscriptional modifications: Evolution, regulation and functionDeficiency of slow skeletal muscle troponin T causes atrophy of type I slow fibres and decreases tolerance to fatigueSimultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicologyDegeneracy allows for both apparent homogeneity and diversification in populationsTNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships.Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans.Characterization of cytoskeleton features and maturation status of cultured human iPSC-derived cardiomyocytes.Coexistence of cardiac troponin T variants reduces heart efficiency.A dominantly negative mutation in cardiac troponin I at the interface with troponin T causes early remodeling in ventricular cardiomyocytesDiminished expression of h2-calponin in prostate cancer cells promotes cell proliferation, migration and the dependence of cell adhesion on substrate stiffnessMutual rescues between two dominant negative mutations in cardiac troponin I and cardiac troponin TTop-down mass spectrometry of cardiac myofilament proteins in health and disease.Abnormal splicing in the N-terminal variable region of cardiac troponin T impairs systolic function of the heart with preserved Frank-Starling compensationDistinct conformational and functional effects of two adjacent pathogenic mutations in cardiac troponin I at the interface with troponin T.NH2-terminal truncations of cardiac troponin I and cardiac troponin T produce distinct effects on contractility and calcium homeostasis in adult cardiomyocytesStructure of the NH2-terminal variable region of cardiac troponin T determines its sensitivity to restrictive cleavage in pathophysiological adaptationDissecting human skeletal muscle troponin proteoforms by top-down mass spectrometry.Correlation of molecular and functional effects of mutations in cardiac troponin T linked to familial hypertrophic cardiomyopathy: an integrative in silico/in vitro approachChronic coexistence of two troponin T isoforms in adult transgenic mouse cardiomyocytes decreased contractile kinetics and caused dilatative remodelingThe N-terminal extension of cardiac troponin T stabilizes the blocked state of cardiac thin filamentTroponin T nuclear localization and its role in aging skeletal muscleStructural determinants of muscle thin filament cooperativity.Molecular evolution of troponin I and a role of its N-terminal extension in nematode locomotion.Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary miceDiscontinuous thoracic venous cardiomyocytes and heart exhibit synchronized developmental switch of troponin isoforms.Nonmyofilament-associated troponin T fragments induce apoptosis.Effect of N-Terminal Extension of Cardiac Troponin I on the Ca(2+) Regulation of ATP Binding and ADP Dissociation of Myosin II in Native Cardiac Myofibrils.Physiological contractility of cardiomyocytes in the wall of mouse and rat azygos vein.
P2860
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P2860
Isoform diversity, regulation, and functional adaptation of troponin and calponin
description
2008 nî lūn-bûn
@nan
2008 թուականին հրատարակուած գիտական յօդուած
@hyw
2008 թվականին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Isoform diversity, regulation, and functional adaptation of troponin and calponin
@ast
Isoform diversity, regulation, and functional adaptation of troponin and calponin
@en
Isoform diversity, regulation, and functional adaptation of troponin and calponin
@nl
type
label
Isoform diversity, regulation, and functional adaptation of troponin and calponin
@ast
Isoform diversity, regulation, and functional adaptation of troponin and calponin
@en
Isoform diversity, regulation, and functional adaptation of troponin and calponin
@nl
prefLabel
Isoform diversity, regulation, and functional adaptation of troponin and calponin
@ast
Isoform diversity, regulation, and functional adaptation of troponin and calponin
@en
Isoform diversity, regulation, and functional adaptation of troponin and calponin
@nl
P2093
P3181
P1476
Isoform diversity, regulation, and functional adaptation of troponin and calponin
@en
P2093
James A Bautista
Jian-Ping Jin
Zhiling Zhang
P304
P3181
P356
10.1615/CRITREVEUKARGENEEXPR.V18.I2.10
P407
P577
2008-01-01T00:00:00Z