Efficient, crosswise catalytic promiscuity among enzymes that catalyze phosphoryl transfer
about
Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics.The alkaline hydrolysis of sulfonate esters: challenges in interpreting experimental and theoretical dataResolving apparent conflicts between theoretical and experimental models of phosphate monoester hydrolysisOne in a million: flow cytometric sorting of single cell-lysate assays in monodisperse picolitre double emulsion droplets for directed evolution.Cooperative Electrostatic Interactions Drive Functional Evolution in the Alkaline Phosphatase Superfamily.Promiscuity in the Enzymatic Catalysis of Phosphate and Sulfate Transfer.The Competing Mechanisms of Phosphate Monoester Dianion HydrolysisSpecificity Effects of Amino Acid Substitutions in Promiscuous Hydrolases: Context-Dependence of Catalytic Residue Contributions to Local Fitness Landscapes in Nearby Sequence Space.Enzyme sub-functionalization driven by regulation.Stabilization of different types of transition states in a single enzyme active site: QM/MM analysis of enzymes in the alkaline phosphatase superfamily.Active Site Hydrophobicity and the Convergent Evolution of Paraoxonase Activity in Structurally Divergent Enzymes: The Case of Serum Paraoxonase 1.Flexibility and reactivity in promiscuous enzymes.Biological messiness vs. biological genius: Mechanistic aspects and roles of protein promiscuity.Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.H2Av facilitates H3S10 phosphorylation but is not required for heat shock-induced chromatin decondensation or transcriptional elongation.Mechanistic and Evolutionary Insights from Comparative Enzymology of Phosphomonoesterases and Phosphodiesterases across the Alkaline Phosphatase SuperfamilyModeling catalytic promiscuity in the alkaline phosphatase superfamily.Differential catalytic promiscuity of the alkaline phosphatase superfamily bimetallo core reveals mechanistic features underlying enzyme evolution.Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester.Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset
P2860
Q27343150-99CF4470-233D-4B3A-B9D1-A11420803B2FQ30702060-66FAC70A-68B3-4F51-9C7A-F754317E5C84Q35031836-825C1F8A-22D4-4BDD-B9F8-042ABA476F95Q35092096-4CB499F4-5C2F-4D6D-B368-F550913AE468Q35669041-A0F66234-A6B0-40AD-8D38-BDAFAC2E376FQ36019839-3FD6CA0C-B9EA-401A-8CBA-11940CBC90A9Q36089437-D447AF9C-B3CC-4C13-842B-8803F2A90813Q36360999-8FC7C4E1-732C-4D03-800D-282D0399B698Q36405739-728ECB01-7100-4DFF-BDA8-AE6FA74199AAQ37137337-9383D9B0-D984-4AA6-BDA6-A9E65D7BCAAEQ37609374-7F01BB3E-543A-4A22-A6D5-D0EFD92DE04DQ38077741-0EB935A0-7F39-4223-BB21-6CEBF9D92495Q38248878-DC814906-B56A-4DCF-AA85-A84FBEB0CA8BQ38287400-59AF74B4-A89D-4FB9-811F-4E45207ACA32Q38625066-D54A6B47-4F13-42D7-90AE-ED9C49554302Q41676786-8017409D-9B81-42A1-A91C-A8CE84D54FE0Q42024162-5850A627-8FEE-47F5-9ABC-A90F2A90B67CQ47410126-37300C9C-FAB0-480B-8437-ED99F65D60A5Q49847175-EB383584-A61D-4A0F-9944-914B19EE77F7Q56889432-0EFAC39D-5743-4CF0-9A0F-D06726217040
P2860
Efficient, crosswise catalytic promiscuity among enzymes that catalyze phosphoryl transfer
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Efficient, crosswise catalytic ...... t catalyze phosphoryl transfer
@ast
Efficient, crosswise catalytic ...... t catalyze phosphoryl transfer
@en
Efficient, crosswise catalytic ...... t catalyze phosphoryl transfer
@nl
type
label
Efficient, crosswise catalytic ...... t catalyze phosphoryl transfer
@ast
Efficient, crosswise catalytic ...... t catalyze phosphoryl transfer
@en
Efficient, crosswise catalytic ...... t catalyze phosphoryl transfer
@nl
prefLabel
Efficient, crosswise catalytic ...... t catalyze phosphoryl transfer
@ast
Efficient, crosswise catalytic ...... t catalyze phosphoryl transfer
@en
Efficient, crosswise catalytic ...... t catalyze phosphoryl transfer
@nl
P3181
P1476
Efficient, crosswise catalytic ...... t catalyze phosphoryl transfer
@en
P2093
Mark F Mohamed
P304
P3181
P356
10.1016/J.BBAPAP.2012.07.015
P407
P577
2012-08-03T00:00:00Z