Down syndrome candidate region 1,a downstream target of VEGF, participates in endothelial cell migration and angiogenesis
about
VEGF stimulates RCAN1.4 expression in endothelial cells via a pathway requiring Ca2+/calcineurin and protein kinase C-deltaDown's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1Down syndrome candidate region 1-like 1 (DSCR1-L1) mimics the inhibitory effects of DSCR1 on calcineurin signaling in endothelial cells and inhibits angiogenesisModulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivoIdentification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo.Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCγ1 and activating NFAT1-dependent RCAN1 expression.Cyclosporin A promotes tumor angiogenesis in a calcineurin-independent manner by increasing mitochondrial reactive oxygen species.Prenatal ultrasound diagnosis of Down syndrome. After major malformations, soft markers, nuchal translucency and skeletal signs, a new vascular sign?Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome.Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1)Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specific molecule-1 as a novel mediator of lymphangiogenesis.Prokineticin 1 modulates IL-8 expression via the calcineurin/NFAT signaling pathwayDown syndrome critical region 1 enhances the proteolytic cleavage of calcineurin.Down's syndrome: protection against cancer and the therapeutic potential of DSCR1.RCAN1-4 is a thyroid cancer growth and metastasis suppressor.Aberrant expression of RCAN1 in Alzheimer's pathogenesis: a new molecular mechanism and a novel drug target.The effect of RCAN1 on the biological behaviors of small cell lung cancer.RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells.RCAN1-4 knockdown attenuates cell growth through the inhibition of Ras signaling.Regulator of calcineurin 1 modulates cancer cell migration in vitro.Down syndrome candidate region 1 increases the stability of the IkappaBalpha protein: implications for its anti-inflammatory effects.Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cellsA major role for RCAN1 in atherosclerosis progressionVEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration.Inflammatory and Immunological parameters in adults with Down syndromeCalcineurin-binding protein Cbp1 directs the specificity of calcineurin-dependent hyphal elongation during mating in Cryptococcus neoformans.RCAN1 in the inverse association between Alzheimer's disease and cancer.
P2860
Q21136325-FF48EB97-66FB-4821-8A19-46F95B3DAD93Q24654657-319EC551-7FBF-4BF1-8541-2132034090ABQ24680331-4C71396E-D796-4A3F-B507-D2A31A36F419Q28505205-4A604A51-11B9-4383-A8B2-1ABC590CC256Q33947920-EDCAF511-4AF3-46E3-888B-373D2BCAA4EAQ34426472-6CFA5C3C-B2A4-42D6-84C1-BE12C879F02BQ34518356-ECB61D5C-6822-49D1-8EE6-5F368A9EAE19Q36238144-674F2857-A14C-4747-B6B2-E0EDBAA9F532Q36344071-68831D72-655F-40FA-9B98-26E545B52F88Q36581939-7F1C1278-3A64-46D0-BFA1-6F8B6298DB47Q36868721-EDDD3EAC-F716-43BE-8069-C8FE5DEADC94Q37254801-3FFAB5A2-034A-4C0C-B2F3-52AA767DD35EQ37290017-DD246E77-DF8D-486B-95B3-865542581457Q37620385-1D06CE66-B0E7-4B4A-B813-D9AE2BAF18FDQ37677411-4ED6C8EC-117D-4247-84A9-80BFC9E89DB1Q38206125-E6BD2314-B3E7-400E-9DD3-9791ED73793FQ38699703-CA741554-8E1E-484C-93B6-88F013414479Q38921964-7335899D-693E-434A-AFDC-5BEE35D7B3A2Q39823032-351B1DF4-56EF-4D73-AC3F-DBC2713F1F7FQ39869583-6E7F520E-6B1A-4861-AB89-AFAA04964C8AQ40216264-D94E25E8-A119-443C-9E74-09F2EBC3B73CQ40218296-9ADD48B9-E5A9-4E25-BE82-ED7D0FBC6121Q41775575-C80D6196-D6E0-4BD7-8F25-7C91228818FFQ41866270-C543F4B1-1202-4A31-BDE6-D2DD65C9E356Q41961850-7005C3C2-CB48-4E4C-A137-6D23E342474FQ42150452-87910E26-3831-4724-AD07-BFA6D3574A5DQ42916950-8FB197CC-9255-416E-A5D5-8082EF5FDAA8Q49247951-B4D213DF-E7D0-45A8-8EA3-CD13973CB28B
P2860
Down syndrome candidate region 1,a downstream target of VEGF, participates in endothelial cell migration and angiogenesis
description
2004 nî lūn-bûn
@nan
2004 թուականին հրատարակուած գիտական յօդուած
@hyw
2004 թվականին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Down syndrome candidate region ...... ell migration and angiogenesis
@ast
Down syndrome candidate region ...... ell migration and angiogenesis
@en
Down syndrome candidate region ...... ell migration and angiogenesis
@nl
type
label
Down syndrome candidate region ...... ell migration and angiogenesis
@ast
Down syndrome candidate region ...... ell migration and angiogenesis
@en
Down syndrome candidate region ...... ell migration and angiogenesis
@nl
prefLabel
Down syndrome candidate region ...... ell migration and angiogenesis
@ast
Down syndrome candidate region ...... ell migration and angiogenesis
@en
Down syndrome candidate region ...... ell migration and angiogenesis
@nl
P2093
P2860
P356
P1476
Down syndrome candidate region ...... ell migration and angiogenesis
@en
P2093
Iwao Sasaki
Kenichi Shiiba
Masashi Iizuka
Mayumi Abe
Yasufumi Sato
P2860
P304
P356
10.1159/000079832
P407
P577
2004-01-01T00:00:00Z