Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase
about
Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigsCrystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesisBinding Modes of Zaragozic Acid A to Human Squalene Synthase and Staphylococcal Dehydrosqualene SynthaseIn vitro antifungal activity and cytotoxicity of a novel membrane-active peptideIdentification and characterization of novel antimicrobial decapeptides generated by combinatorial chemistryComparison of Chemical Sensitivity of Fresh and Long-Stored Heat Resistant Neosartorya fischeri Environmental Isolates Using BIOLOG Phenotype MicroArray SystemEnhanced production of farnesol by Candida albicans treated with four azoles.A chemical ecogenomics approach to understand the roles of secondary metabolites in fungal cereal pathogens.Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.A new approach to the molecular analysis of docking, priming, and regulated membrane fusionFarnesol biosynthesis in Candida albicans: cellular response to sterol inhibition by zaragozic acid B.In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi.Possibility of bacterial recruitment of plant genes associated with the biosynthesis of secondary metabolites.Quorum sensing in dimorphic fungi: farnesol and beyondCloning, solubilization, and characterization of squalene synthase from Thermosynechococcus elongatus BP-1Cryptosporidium parvum scavenges LDL-derived cholesterol and micellar cholesterol internalized into enterocytes.Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphateSterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs.Regulation of dolichol-linked glycosylation.Identification of Novel Raft Marker Protein, FlotP in Bacillus anthracis.Digoxin and ouabain induce the efflux of cholesterol via liver X receptor signalling and the synthesis of ATP in cardiomyocytes.In Vitro Antimalarial Activity of Different Inhibitors of the Plasmodial Isoprenoid Synthesis Pathway.YM-53601, a novel squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in several animal species.The administration of drugs inhibiting cholesterol/oxysterol synthesis is safe and increases the efficacy of immunotherapeutic regimens in tumor-bearing mice.Engineered biosynthesis of phenyl-substituted polyketides.Building terpene production platforms in yeast.Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway.Biodiversity and chemotaxonomy of Preussia isolates from the Iberian Peninsula
P2860
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P2860
Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase
description
1995 nî lūn-bûn
@nan
1995 թուականին հրատարակուած գիտական յօդուած
@hyw
1995 թվականին հրատարակված գիտական հոդված
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1995年の論文
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1995年学术文章
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1995年学术文章
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1995年学术文章
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1995年学术文章
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1995年学术文章
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1995年學術文章
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name
Discovery, biosynthesis, and m ...... nhibitors of squalene synthase
@ast
Discovery, biosynthesis, and m ...... nhibitors of squalene synthase
@en
Discovery, biosynthesis, and m ...... nhibitors of squalene synthase
@nl
type
label
Discovery, biosynthesis, and m ...... nhibitors of squalene synthase
@ast
Discovery, biosynthesis, and m ...... nhibitors of squalene synthase
@en
Discovery, biosynthesis, and m ...... nhibitors of squalene synthase
@nl
prefLabel
Discovery, biosynthesis, and m ...... nhibitors of squalene synthase
@ast
Discovery, biosynthesis, and m ...... nhibitors of squalene synthase
@en
Discovery, biosynthesis, and m ...... nhibitors of squalene synthase
@nl
P2093
P1476
Discovery, biosynthesis, and m ...... nhibitors of squalene synthase
@en
P2093
C Dufresne
J D Bergstrom
M Nallin-Omstead
P304
P356
10.1146/ANNUREV.MI.49.100195.003135
P407
P577
1995-01-01T00:00:00Z