Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia
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A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1Evi27 encodes a novel membrane protein with homology to the IL17 receptorOverexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemiaCloning and expression of a new HOXC6 transcript encoding a repressing proteinNup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assemblyDEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancerNucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 RevCREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicityHoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalizationDifferential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1Identification and characterization of Hoxa9 binding sites in hematopoietic cellsAbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteinsThe homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesisFusion of the NUP98 gene with the LEDGF/p52 gene defines a recurrent acute myeloid leukemia translocationNup116p and nup100p are interchangeable through a conserved motif which constitutes a docking site for the mRNA transport factor gle2p.The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear importA set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activitiesTALE homeoproteins as HOX11-interacting partners in T-cell leukemiaHuman HOX gene mutationsThe chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9A conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1Survival regulation of leukemia stem cellsThe role of NUP98 gene fusions in hematologic malignancyHigh levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming eventThe HoxB1 hexapeptide is a prefolded domain: implications for the Pbx1/Hox interactionParalogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancyMeis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteinsHematopoietic, angiogenic and eye defects in Meis1 mutant animals.Bmi-1 determines the proliferative capacity of normal and leukaemic stem cellsHoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation.Imaging hematopoietic precursor division in real time.Candidate genes for expansion and transformation of hematopoietic stem cells by NUP98-HOX fusion genes.Dissection of the transformation of primary human hematopoietic cells by the oncogene NUP98-HOXA9The peripheral cannabinoid receptor, Cb2, in retrovirally-induced leukemic transformation and normal hematopoiesis.Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2.High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia.Delineating domains and functions of NUP98 contributing to the leukemogenic activity of NUP98-HOX fusionsHOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.
P2860
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P2860
Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia
description
1996 nî lūn-bûn
@nan
1996 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
name
Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia
@ast
Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia
@en
Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia
@nl
type
label
Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia
@ast
Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia
@en
Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia
@nl
prefLabel
Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia
@ast
Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia
@en
Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia
@nl
P2093
P2860
P3181
P356
P1433
P1476
Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia
@en
P2093
A P Feinberg
C L Willman
D A Largaespada
J D Shaughnessy
K Ohyashiki
L A Johnson
N A Jenkins
P2860
P2888
P3181
P356
10.1038/NG0296-154
P407
P577
1996-02-01T00:00:00Z
P5875
P6179
1042508829