ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
about
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) familyLong-term cyclical in vivo loading increases cartilage proteoglycan content in a spatially specific manner: an infrared microspectroscopic imaging and polarized light microscopy studyInhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulinADAMTS-12 associates with and degrades cartilage oligomeric matrix proteinExpression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumoursHistone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorptionThe Function and Roles of ADAMTS-7 in Inflammatory DiseasesTGF-β signaling in C. elegansADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinomaThe ADAMTS metalloproteinasesIdentification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate.ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the 'usual suspects'.ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury.Metabolism of cartilage proteoglycans in health and diseaseADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis.ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix proteinADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.C. elegans ADAMTS ADT-2 regulates body size by modulating TGFβ signaling and cuticle collagen organization.ADAMTS expression in colorectal cancerProteases involved in cartilage matrix degradation in osteoarthritis.Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage.The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury.Emerging Roles of ADAMTSs in Angiogenesis and Cancer.Downregulation of ADAMTS8 by DNA Hypermethylation in Gastric Cancer and Its Clinical Significance.ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor.The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases.Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage.Biochemical markers and the FDA Critical Path: how biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development.The transcriptome of cervical ripening in human pregnancy before the onset of labor at term: identification of novel molecular functions involved in this process.The roles of ADAMTS in angiogenesis and cancer.The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells.Lentiviral shRNA knock-down of ADAMTS-5 and -9 restores matrix deposition in 3D chondrocyte culture.Characterization and regulation of ADAMTS-16.Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activityEffect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model.Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2.A quantitative assay for aggrecanase activity.Transcriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis.Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice.
P2860
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P2860
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
@ast
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
@en
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
@nl
type
label
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
@ast
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
@en
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
@nl
prefLabel
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
@ast
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
@en
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
@nl
P2093
P3181
P1433
P1476
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
@en
P2093
Andrew J Dorner
Bethany Annis-Freeman
Carl R Flannery
Chris Corcoran
Edward R LaVallie
Elisabeth A Morris
Elizabeth DiBlasio-Smith
Katy E Georgiadis
Lisa A Collins-Racie
P304
P3181
P356
10.1016/J.MATBIO.2004.05.004
P407
P577
2004-07-01T00:00:00Z