Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
about
Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptidePresenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylationMicroglial cell dysregulation in brain aging and neurodegenerationA novel carboxypeptidase B that processes native beta-amyloid precursor protein is present in human hippocampusInflammation and Alzheimer's diseaseDe novo generation of prion strainsAbeta mediated diminution of MTT reduction--an artefact of single cell culture?Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutationGene expression of cyclooxygenase-1 and Ca(2+)-independent phospholipase A(2) is altered in rat hippocampus during normal agingAgeing increases vulnerability to aβ42 toxicity in DrosophilaCats, "rats," and bats: the comparative biology of aging in the 21st centuryNatural oligomers of the amyloid-beta protein specifically disrupt cognitive functionA beta oligomers - a decade of discoveryMassive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic modelHuman brain carboxypeptidase B, which cleaves beta-amyloid peptides in vitro, is expressed in the endoplasmic reticulum of neurons.Design and characterization of a membrane permeable N-methyl amino acid-containing peptide that inhibits Abeta1-40 fibrillogenesis.Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.Interactions between amyloid-β and hemoglobin: implications for amyloid plaque formation in Alzheimer's disease.Mechanism of accelerated assembly of beta-amyloid filaments into fibrils by KLVFFK(6).Sequence determinants of enhanced amyloidogenicity of Alzheimer A{beta}42 peptide relative to A{beta}40.Fibrillar beta-amyloid peptide Abeta1-40 activates microglial proliferation via stimulating TNF-alpha release and H2O2 derived from NADPH oxidase: a cell culture studyThe Sixth International Conference on Alzheimer's disease, Amsterdam, The Netherlands, July 1998. The amyloid cascade hypothesis debate: emerging consensus on the role of A beta and amyloid in Alzheimer's disease.A resorcinarene for inhibition of Aβ fibrillation.The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease.Marginal Vitamin A Deficiency Exacerbates Memory Deficits Following Aβ1-42 Injection in Rats.Alzheimer's disease and the amyloid beta protein: What is the role of amyloid?Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.Tau pathology generated by overexpression of tau.An update on the amyloid hypothesis.Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice.Preclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics.beta-Amyloid excitotoxicity in rat magnocellular nucleus basalis. Effect of cortical deafferentation on cerebral blood flow regulation and implications for Alzheimer's disease.Microglia activation mediates fibrillar amyloid-β toxicity in the aged primate cortex.Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's diseaseNeuronal and axonal loss are selectively linked to fibrillar amyloid-{beta} within plaques of the aged primate cerebral cortex.Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease.Untangling Alzheimer's disease from fibrous lesions of neurofibrillary tangles and senile plaques.Oleocanthal, a phenolic derived from virgin olive oil: a review of the beneficial effects on inflammatory diseaseCerebral amyloid β(42) deposits and microvascular pathology in ageing baboons.
P2860
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P2860
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
description
1998 nî lūn-bûn
@nan
1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
@ast
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
@en
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
@nl
type
label
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
@ast
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
@en
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
@nl
prefLabel
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
@ast
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
@en
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
@nl
P2093
P3181
P356
P1433
P1476
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
@en
P2093
P2860
P2888
P304
P3181
P356
10.1038/NM0798-827
P407
P577
1998-07-01T00:00:00Z